Daidzein phosphorylates and activates 5-lipoxygenase via the MEK/ERK pathway: a mechanism for inducing the production of 5-lipoxygenase metabolite that inhibit influenza virus intracellular replication.

Humans Adenosine Triphosphate / metabolism Arachidonate 12-Lipoxygenase / metabolism Arachidonate 5-Lipoxygenase / drug effects Arachidonic Acid / metabolism Isoflavones / pharmacology MAP Kinase Signaling System / drug effects Mitogen-Activated Protein Kinase Kinases / metabolism Influenza, Human / metabolism
5-hydroxyeicosatetraenoic acid 5-lipoxygenase Influenza virus MEK/ERK signal transduction pathway Soy isoflavone daidzein

Journal

The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081

Informations de publication

Date de publication:
04 2023
Historique:
received: 03 06 2022
revised: 01 12 2022
accepted: 13 01 2023
pubmed: 23 1 2023
medline: 7 3 2023
entrez: 22 1 2023
Statut: ppublish

Résumé

We previously reported that the soy isoflavone daidzein (Dz) suppresses the intracellular replication of influenza virus and that arachidonic acid-derived oxidation product via lipid oxidase 5-lipoxygenase (5-LOX) is involved in its antiviral effect. The activation of 5-LOX by Dz triggers anti-influenza activity; however, the mechanism of activation of 5-LOX remains unclear. Therefore, in this study, we aimed to clarify the activation mechanism using human monocyte-derived THP-1 cells differentiated using phorbol 12-myristate 13-acetate. THP-1 cells expressed 5-LOX endogenously and Dz did not induce 5-LOX expression. However, 8 h after treatment with Dz, the amount of 5-hydroxyeicosatetraenoic acid (5-HETE), an arachidonic acid oxidation product via 5-LOX, increased significantly suggesting that the enzyme is activated regardless of changes in 5-LOX protein levels. Intracellular Ca

Identifiants

DOI: 10.1016/j.jnutbio.2023.109276 PMID: 36682398
pubmed: 36682398
pii: S0955-2863(23)00010-4
doi: 10.1016/j.jnutbio.2023.109276
pii:
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE
Arachidonate 12-Lipoxygenase EC 1.13.11.31
Arachidonate 5-Lipoxygenase EC 1.13.11.34
Arachidonic Acid 27YG812J1I
daidzein 6287WC5J2L
Isoflavones 0
Mitogen-Activated Protein Kinase Kinases EC 2.7.12.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109276

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Yuka Horio (Y)

Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan; Department of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.

Yuji Isegawa (Y)

Department of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo, Japan. Electronic address: isegawa@mukogawa-u.ac.jp.

Mototada Shichiri (M)

Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan. Electronic address: mototada-shichiri@aist.go.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Daidzein phosphorylates and activates...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Daidzein phosphorylates and activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Arachidonate 12-lipoxygenase › Daidzein phosphorylates and activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Arachidonate 5-lipoxygenase › Daidzein phosphorylates and activates...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras indispensables › Acides arachidoniques › Acide arachidonique › Daidzein phosphorylates and activates...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Isoflavones › Daidzein phosphorylates and activates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Daidzein phosphorylates and activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Mitogen-Activated Protein Kinase Kinases › Daidzein phosphorylates and activates...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › Daidzein phosphorylates and activates...