Successful Treatment with Letermovir in a Heart Transplant Recipient with UL97 Mutation Ganciclovir-Resistant Cytomegalovirus Colitis and Viremia.

Humans Ganciclovir / therapeutic use Antiviral Agents / therapeutic use Viremia / drug therapy Cytomegalovirus Infections / drug therapy Cytomegalovirus / genetics Mutation Heart Transplantation / adverse effects
Acute cellular rejection Chronic kidney disease Cytomegalovirus-pp65 antigenemia Heart transplantation

Journal

International heart journal
ISSN: 1349-3299
Titre abrégé: Int Heart J
Pays: Japan
ID NLM: 101244240

Informations de publication

Date de publication:
31 Mar 2023
Historique:
medline: 4 4 2023
pubmed: 23 1 2023
entrez: 22 1 2023
Statut: ppublish

Résumé

Currently available anti-cytomegalovirus (CMV) agents are sometimes poorly tolerated, owing to their side effects. Letermovir is a novel anti-CMV drug that is only approved for CMV prophylaxis in hematopoietic stem cell transplant recipients, with fewer side effects. We report the case of a heart transplant recipient with UL97 mutation (L595F) ganciclovir-resistant cytomegalovirus colitis who was successfully treated with off-label use of letermovir. In treating CMV infection or disease with letermovir, a transient rise or lag in the clearance of CMV-DNA polymerase chain reaction levels has been observed. Our case suggests that CMV-pp65 antigenemia can be an additional marker of treatment efficacy.

Identifiants

DOI: 10.1536/ihj.22-496 PMID: 36682771
pubmed: 36682771
doi: 10.1536/ihj.22-496
doi:

Substances chimiques

Ganciclovir P9G3CKZ4P5
letermovir 1H09Y5WO1F
Antiviral Agents 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

95-99

Auteurs

Tomonobu Yanase (T)

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Masaru Hatano (M)

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
Advanced Medical Center for Heart Failure, The University of Tokyo Hospital.

Chie Bujo (C)

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Masaki Tsuji (M)

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Junichi Ishida (J)

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Eisuke Amiya (E)

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
Department of Therapeutic Strategy for Heart Failure, The University of Tokyo.

Koh Okamoto (K)

Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo.

Masahiko Ando (M)

Department of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo.

Shogo Shimada (S)

Department of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo.

Osamu Kinoshita (O)

Department of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo.

Shuetsu Fukushi (S)

Department of Virology 1, National Institute of Infectious Diseases.

Souichi Yamada (S)

Department of Virology 1, National Institute of Infectious Diseases.

Minoru Ono (M)

Department of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo.

Issei Komuro (I)

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Successful Treatment with Letermovir in a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Hypoxanthines › Guanine › Aciclovir › Ganciclovir › Successful Treatment with Letermovir in a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Successful Treatment with Letermovir in a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Virémie › Successful Treatment with Letermovir in a...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ADN › Infections à Herpesviridae › Infections à cytomégalovirus › Successful Treatment with Letermovir in a...
questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Successful Treatment with Letermovir in a...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Successful Treatment with Letermovir in a...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Transplantation cardiaque › Successful Treatment with Letermovir in a...