A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice.
Chi3l1
acetaminophen
antibody therapy
humanized antibody
liver injury
rabbit antibody
Journal
Antibody therapeutics
ISSN: 2516-4236
Titre abrégé: Antib Ther
Pays: United States
ID NLM: 101730822
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
01
08
2022
revised:
24
10
2022
accepted:
27
10
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
Acetaminophen (APAP) overdose is a leading cause of acute liver injury in the USA. The chitinase 3-like-1 (Chi3l1) protein contributes to APAP-induced liver injury (AILI) by promoting hepatic platelet recruitment. Here, we report the development of a Chi3l1-targeting antibody as a potential therapy for AILI. By immunizing a rabbit successively with the human and mouse Chi3l1 proteins, we isolated cross-reactive monoclonal antibodies (mAbs) from single memory B cells. One of the human and mouse Chi3l1 cross-reactive mAbs was humanized and characterized in both
Identifiants
pubmed: 36683763
doi: 10.1093/abt/tbac027
pii: tbac027
pmc: PMC9847341
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-12Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK121330
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122708
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007392
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Antibody Therapeutics. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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