Estrone, sex hormone binding globulin and lipid profiles in older women: an observational study.
Menopause
cholesterol
estrone
lipids
sex hormone binding globulin
Journal
Climacteric : the journal of the International Menopause Society
ISSN: 1473-0804
Titre abrégé: Climacteric
Pays: England
ID NLM: 9810959
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
pmc-release:
01
04
2024
pubmed:
25
1
2023
medline:
24
3
2023
entrez:
24
1
2023
Statut:
ppublish
Résumé
We investigated whether estrone and sex hormone binding globulin (SHBG) concentrations are associated with lipid concentrations in older postmenopausal women. This was a cross-sectional study of 6358 Australian women, aged 70-95 years, recruited between 2010 and 2014. Associations between estrone and SHBG and lipid concentrations were examined in participants not using medications that influence estrogen concentrations or lipid-lowering therapy. Linear regression models included age, body mass index, smoking, alcohol consumption, renal function and diabetes, with the lowest quartile (Q1) as the reference for estrone and SHBG. The study included 3231 participants with median age of 74.0 (interquartile range 71.7-77.9) years. Estrone concentration Q3 and Q4 were positively associated with high-density lipoprotein cholesterol (HDL-C) ( Estrone and SHBG are associated with lipid concentrations in older women. SHBG, but not estrone, may provide additional clinical predictive utility for the assessment of cardiometabolic disease risk in older women.
Identifiants
pubmed: 36693423
doi: 10.1080/13697137.2023.2165908
pmc: PMC10033393
mid: NIHMS1879801
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Cholesterol, HDL
0
Estradiol
4TI98Z838E
Estrone
2DI9HA706A
Lipoproteins
0
Sex Hormone-Binding Globulin
0
Testosterone
3XMK78S47O
Triglycerides
0
SHBG protein, human
0
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114-120Subventions
Organisme : NIA NIH HHS
ID : U01 AG029824
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG062682
Pays : United States
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