Hepatic and pulmonary involvement in a patient with PR3-ANCA vasculitis following SARS-CoV-2 vaccination: A case report.


Journal

Modern rheumatology case reports
ISSN: 2472-5625
Titre abrégé: Mod Rheumatol Case Rep
Pays: England
ID NLM: 101761026

Informations de publication

Date de publication:
19 06 2023
Historique:
received: 29 09 2022
revised: 21 12 2022
accepted: 11 01 2023
medline: 21 6 2023
pubmed: 26 1 2023
entrez: 25 1 2023
Statut: ppublish

Résumé

We here report the first case of anti-proteinase 3-positive anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis following the severe acute respiratory syndrome coronavirus 2 Pfizer-BioNTech vaccine presenting with prominent liver involvement and alveolar haemorrhage. Two weeks after vaccination, a 49-year-old man developed inflammatory arthralgias and hypertransaminasaemia. Two months later, fever and haemoptysis appeared; the patient tested positive for anti-proteinase 3 autoantibodies. High-dose steroids and rituximab were started, and complete remission was achieved. Systemic autoimmune diseases, including ANCA-associated vasculitis, should always be considered in the differential diagnosis of hypertransaminasaemia, especially when the clinical context is suspicious.

Identifiants

pubmed: 36695552
pii: 7005160
doi: 10.1093/mrcr/rxad005
doi:

Substances chimiques

Antibodies, Antineutrophil Cytoplasmic 0
COVID-19 Vaccines 0
Myeloblastin EC 3.4.21.76

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

440-443

Informations de copyright

© Japan College of Rheumatology 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Auteurs

Antonio Tonutti (A)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
IRCCS Humanitas Research Hospital, Rozzano, Italy.

Edoardo Simonetta (E)

Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Anna Stainer (A)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Giulia Suigo (G)

Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Maria De Santis (M)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Carlo Selmi (C)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Chiara Masetti (C)

Liver Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Ana Lleo (A)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Liver Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Luigi Maria Terracciano (LM)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Institute of Pathology, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Stefano Aliberti (S)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Francesco Amati (F)

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.

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Classifications MeSH