Plasmonic-Magnetic Active Nanorheology for Intracellular Viscosity.

cancer cells magnetic nanorheology plasmonic viscosity

Journal

Nano letters
ISSN: 1530-6992
Titre abrégé: Nano Lett
Pays: United States
ID NLM: 101088070

Informations de publication

Date de publication:
08 03 2023
Historique:
pubmed: 26 1 2023
medline: 10 3 2023
entrez: 25 1 2023
Statut: ppublish

Résumé

We demonstrate active plasmonic systems where plasmonic signals are repeatedly modulated by changing the orientation of nanoprobes under an external magnetic field, which is a prerequisite for in situ active nanorheology in intracellular viscosity measurements. Au/Ni/Au nanorods act as "nanotransmitters", which transmit the mechanical motion of nanorods to an electromagnetic radiation signal as a periodic sine function. This fluctuating optical response is transduced to frequency peaks via Fourier transform surface plasmon resonance (FTSPR). As a driving frequency of the external magnetic field applied to the Au/Ni/Au nanorods increases and reaches above a critical threshold, there is a transition from the synchronous motion of nanorods to asynchronous responses, leading to the disappearance of the FTSPR peak, which allows us to measure the local viscosity of the complex fluids. Using this ensemble-based method with plasmonic functional nanomaterials, we measure the intracellular viscosity of cancer cells and normal cells in a reliable and reproducible manner.

Identifiants

pubmed: 36695563
doi: 10.1021/acs.nanolett.2c04761
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2031-2038

Auteurs

Sungwoo Lee (S)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Institute of Basic Science, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Insub Jung (I)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Institute of Basic Science, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Soohyun Lee (S)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Junghyun Shin (J)

Department of Physics and Astronomy, Institute of Applied Physics, Seoul National University (SNU), Seoul 08826, Republic of Korea.

Eunbyeol Cho (E)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Sangbaek Jung (S)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Seongkeun Ih (S)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Yang-Gyun Kim (YG)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Seunghun Hong (S)

Department of Physics and Astronomy, Institute of Applied Physics, Seoul National University (SNU), Seoul 08826, Republic of Korea.

Yoon-La Choi (YL)

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University (SKKU), Seoul 06355, Republic of Korea.
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.

Sungho Park (S)

Department of Chemistry, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

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Classifications MeSH