Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark.
Journal
JAMA network open
ISSN: 2574-3805
Titre abrégé: JAMA Netw Open
Pays: United States
ID NLM: 101729235
Informations de publication
Date de publication:
03 01 2023
03 01 2023
Historique:
entrez:
25
1
2023
pubmed:
26
1
2023
medline:
28
1
2023
Statut:
epublish
Résumé
Sudden infant death syndrome (SIDS) remains a leading cause of death during the first year of life. The etiology of SIDS is complex and remains largely unknown. To evaluate whether siblings of children who died of SIDS have a higher risk of SIDS compared with the general pediatric population. This register-based cohort study used Danish nationwide registers. Participants were all infants (<1 year) in Denmark between January 1, 1978, and December 31, 2016, including siblings of children who died of SIDS. Siblings were followed up from the index cases' date of SIDS, date of birth, or immigration, whichever came first, and until age 1 year, emigration, developing SIDS, death, or study end. The median (IQR) follow-up was 1 (1-1) year. Data analysis was conducted from January 2017 to October 2022. Standardized incidence ratios (SIRs) of SIDS were calculated with Poisson regression models relative to the general population. In a population of 2 666 834 consecutive births (1 395 199 [52%] male), 1540 infants died of SIDS (median [IQR] age at SIDS, 3 [2-4] months) during a 39-year study period. A total of 2384 younger siblings (cases) to index cases (first sibling with SIDS) were identified. A higher rate of SIDS was observed among siblings compared with the general population, with SIRs of 4.27 (95% CI, 2.13-8.53) after adjustment for sex, age, and calendar year and of 3.50 (95% CI, 1.75-7.01) after further adjustment for mother's age (<29 years vs ≥29 years) and education (high school vs after high school). In this nationwide study, having a sibling who died of SIDS was associated with a 4-fold higher risk of SIDS compared with the general population. Shared genetic and/or environmental factors may contribute to the observed clustering of SIDS. The family history of SIDS should be considered when assessing SIDS risk in clinical settings. A multidisciplinary genetic evaluation of families with SIDS could provide additional evidence.
Identifiants
pubmed: 36696110
pii: 2800727
doi: 10.1001/jamanetworkopen.2022.52724
pmc: PMC10187488
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2252724Références
J Paediatr Child Health. 2017 Feb;53(2):112-115
pubmed: 28028890
Lancet. 2007 Nov 3;370(9598):1578-87
pubmed: 17980736
JAMA Pediatr. 2017 Feb 1;171(2):204
pubmed: 28166332
Am J Forensic Med Pathol. 2000 Dec;21(4):395-400
pubmed: 11111805
Eur J Hum Genet. 2017 Apr;25(4):404-409
pubmed: 28074886
Heart Rhythm. 2014 Dec;11(12):2316-21
pubmed: 25239430
Epidemiology. 2007 Nov;18(6):800-4
pubmed: 18049194
Pediatrics. 2002 Nov;110(5):e64
pubmed: 12415070
JAMA. 2001 Nov 14;286(18):2264-9
pubmed: 11710892
Lancet. 2005 Jan 1-7;365(9453):29-35
pubmed: 15639677
Int J Legal Med. 2022 Jan;136(1):169-178
pubmed: 34350495
Natl Vital Stat Rep. 2015 Aug 6;64(9):1-30
pubmed: 26270610
Heart Rhythm. 2013 Dec;10(12):1932-63
pubmed: 24011539
Pediatrics. 2016 Jan;137(1):
pubmed: 26634772
N Engl J Med. 2009 Aug 20;361(8):795-805
pubmed: 19692691
Lancet. 2006 Jan 28;367(9507):314-9
pubmed: 16443038
Heart Rhythm. 2014 Dec;11(12):2322-7
pubmed: 25239431
Biol Neonate. 1994;65(3-4):194-7
pubmed: 8038282
Genet Med. 2019 Mar;21(3):641-649
pubmed: 30139991
Pediatr Res. 2016 Jul;80(1):77-84
pubmed: 26959483
Am J Epidemiol. 1988 Mar;127(3):674-83
pubmed: 3341366
MMWR Surveill Summ. 2009 May 29;58(4):1-29
pubmed: 19478726
Heart Rhythm. 2015 Jun;12(6):1241-9
pubmed: 25757662
Pediatrics. 1993 May;91(5):893-6
pubmed: 8474808
BMJ. 1996 Jul 27;313(7051):195-8
pubmed: 8696194
Eur J Epidemiol. 2018 Jan;33(1):27-36
pubmed: 29349587
J Am Coll Cardiol. 2018 Mar 20;71(11):1217-1227
pubmed: 29544605
Int J Cardiol. 2011 Oct 20;152(2):162-70
pubmed: 21215473
Pediatrics. 1989 Dec;84(6):1038-44
pubmed: 2587132
Natl Vital Stat Rep. 2014 Sep 24;63(5):1-6
pubmed: 25252091
Scand J Public Health. 2011 Jul;39(7 Suppl):12-6
pubmed: 21898916
JAMA. 1998 Jul 22-29;280(4):329-35
pubmed: 9686549
Arch Dis Child. 2020 Oct;105(10):945-950
pubmed: 32527717
J Arrhythm. 2021 Apr 08;37(3):481-534
pubmed: 34141003
Arch Dis Child. 2006 Nov;91(11):915-9
pubmed: 16464961
Cardiology. 2011;119(1):21-33
pubmed: 21778721
Eur J Hum Genet. 2016 Jun;24(6):817-22
pubmed: 26350513
Genome Med. 2010 Nov 30;2(11):86
pubmed: 21122164
Pediatrics. 1987 Sep;80(3):355-8
pubmed: 3627886
J Pediatr. 2018 Dec;203:423-428.e11
pubmed: 30268395
Pediatrics. 2004 Jul;114(1):234-8
pubmed: 15231934
World J Pediatr. 2015 Feb;11(1):41-7
pubmed: 25447630
Europace. 2016 May;18(5):658-64
pubmed: 26559919
Heart Rhythm. 2009 Feb;6(2):272-8
pubmed: 18823823
Scand J Public Health. 2011 Jul;39(7 Suppl):91-4
pubmed: 21775362
Lancet. 2018 Apr 14;391(10129):1483-1492
pubmed: 29605429
Scand J Public Health. 2011 Jul;39(7 Suppl):103-5
pubmed: 21775365
Scand Cardiovasc J. 2011 Feb;45(1):14-20
pubmed: 21133644
BMJ. 1990 Jul 14;301(6743):85-9
pubmed: 2390588
Nat Rev Cardiol. 2017 Dec;14(12):715-726
pubmed: 28880023
Forensic Sci Med Pathol. 2008;4(2):83-90
pubmed: 19291477
J Am Heart Assoc. 2020 Jan 7;9(1):e012264
pubmed: 31865891
Scand J Public Health. 2011 Jul;39(7 Suppl):22-5
pubmed: 21775345
Arch Dis Child. 1988 Aug;63(8):924-30
pubmed: 3415329
Front Immunol. 2015 Feb 20;6:63
pubmed: 25750641
Ann Intern Med. 2016 Sep 20;165(6):390-8
pubmed: 27379577
Forensic Sci Med Pathol. 2011 Mar;7(1):26-36
pubmed: 20623341
Mayo Clin Proc. 2012 Jun;87(6):524-39
pubmed: 22677073
Virchows Arch. 2006 Dec;449(6):697-706
pubmed: 17091255
Scand J Public Health. 2011 Jul;39(7 Suppl):26-9
pubmed: 21775346
Natl Vital Stat Rep. 2016 Feb 10;65(1):1-14
pubmed: 26905977
Am J Epidemiol. 1996 Aug 1;144(3):300-5
pubmed: 8686699
Dan Med J. 2012 Feb;59(2):B4403
pubmed: 22293060
Int J Legal Med. 2012 Mar;126(2):271-7
pubmed: 22037935
Pediatrics. 2006 Jul;118(1):421-7
pubmed: 16818592
Pediatrics. 2016 Nov;138(5):
pubmed: 27940805