Reperfusion injury in acute ischemic stroke: Tackling the irony of revascularization.
Ischemic stroke
Reperfusion injury
Revascularization
Thrombectomy
Journal
Clinical neurology and neurosurgery
ISSN: 1872-6968
Titre abrégé: Clin Neurol Neurosurg
Pays: Netherlands
ID NLM: 7502039
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
07
04
2022
revised:
12
12
2022
accepted:
23
12
2022
pubmed:
26
1
2023
medline:
7
3
2023
entrez:
25
1
2023
Statut:
ppublish
Résumé
Reperfusion injury is an unfortunate consequence of restoring blood flow to tissue after a period of ischemia. This phenomenon can occur in any organ, although it has been best studied in cardiac cells. Based on cardiovascular studies, neuroprotective strategies have been developed. The molecular biology of reperfusion injury remains to be fully elucidated involving several mechanisms, however these mechanisms all converge on a similar final common pathway: blood brain barrier disruption. This results in an inflammatory cascade that ultimately leads to a loss of cerebral autoregulation and clinical worsening. In this article, the authors present an overview of these mechanisms and the current strategies being employed to minimize injury after restoration of blood flow to compromised cerebral territories.
Identifiants
pubmed: 36696846
pii: S0303-8467(22)00455-3
doi: 10.1016/j.clineuro.2022.107574
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107574Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Conflicts of interest None.