T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
27 01 2023
27 01 2023
Historique:
entrez:
27
1
2023
pubmed:
28
1
2023
medline:
1
2
2023
Statut:
ppublish
Résumé
Marginal zone (MZ) B cells are one of the main actors of T-independent (TI) responses in mice. To identify the B cell subset(s) involved in such responses in humans, we vaccinated healthy individuals with Pneumovax, a model TI vaccine. By high-throughput repertoire sequencing of plasma cells (PCs) isolated 7 days after vaccination and of different B cell subpopulations before and after vaccination, we show that the PC response mobilizes large clones systematically, including an immunoglobulin M component, whose diversification and amplification predated the pneumococcal vaccination. These clones could be mainly traced back to MZ B cells, together with clonally related IgA
Identifiants
pubmed: 36706172
doi: 10.1126/sciimmunol.ade1413
pmc: PMC7614366
mid: EMS172514
doi:
Substances chimiques
Antigens, Bacterial
0
Pneumococcal Vaccines
0
Polysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eade1413Subventions
Organisme : European Research Council
ID : 693267
Pays : International
Commentaires et corrections
Type : CommentIn
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