Chronic stress in solid tumor development: from mechanisms to interventions.
Cancer treatment
Chronic stress
Tumor development
Tumor microenvironment
Journal
Journal of biomedical science
ISSN: 1423-0127
Titre abrégé: J Biomed Sci
Pays: England
ID NLM: 9421567
Informations de publication
Date de publication:
28 Jan 2023
28 Jan 2023
Historique:
received:
28
10
2022
accepted:
17
01
2023
entrez:
28
1
2023
pubmed:
29
1
2023
medline:
1
2
2023
Statut:
epublish
Résumé
Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggravates disease progression and hinders treatment effects. Recent studies have shown that chronic stress-regulated neuroendocrine systems secret hormones to activate many signaling pathways related to tumor development in tumor cells. The activated neuroendocrine system acts not only on tumor cells but also modulates the survival and metabolic changes of surrounding non-cancerous cells. Current clinical evidences also suggest that chronic stress affects the outcome of cancer treatment. However, in clinic, there is lack of effective treatment for chronic stress in cancer patients. In this review, we discuss the main mechanisms by which chronic stress regulates the tumor microenvironment, including functional regulation of tumor cells by stress hormones (stem cell-like properties, metastasis, angiogenesis, DNA damage accumulation, and apoptotic resistance), metabolic reprogramming and immune escape, and peritumor neuromodulation. Based on the current clinical treatment framework for cancer and chronic stress, we also summarize pharmacological and non-pharmacological therapeutic approaches to provide some directions for cancer therapy.
Identifiants
pubmed: 36707854
doi: 10.1186/s12929-023-00903-9
pii: 10.1186/s12929-023-00903-9
pmc: PMC9883141
doi:
Substances chimiques
Hormones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8Subventions
Organisme : National Natural Science Foundation of China
ID : 81972479
Organisme : National Natural Science Foundation of China
ID : U2004118
Organisme : National Natural Science Foundation of China
ID : 82072899
Organisme : Natural Science Foundation of Guangdong Province
ID : 2019A1515011100
Organisme : Natural Science Foundation of Guangdong Province
ID : 2021A1515012576
Organisme : Henan Natural Science Foundation
ID : 202300410359
Organisme : Henan Medical Research Program
ID : SBGJ2020002081
Organisme : Guangzhou High-Level Clinical Key Specialty Construction Project: Clinical Key Specialty Construction Project of Guangzhou Medical University
ID : 202005
Organisme : the Innovation Project of Universities in Guangdong Province
ID : 2021KTSCX026
Informations de copyright
© 2023. The Author(s).
Références
Immunology. 2018 Jul;154(3):383-393
pubmed: 29512837
J Clin Oncol. 2013 Sep 1;31(25):3119-26
pubmed: 23918953
Science. 2013 Jul 12;341(6142):1236361
pubmed: 23846904
J Clin Oncol. 2020 Mar 10;38(8):804-814
pubmed: 31855498
Nat Commun. 2018 Oct 16;9(1):4284
pubmed: 30327461
Breast Cancer Res. 2014 Apr 14;16(2):R39
pubmed: 24731917
Clin Cancer Res. 2013 Nov 15;19(22):6163-72
pubmed: 24016618
Br J Cancer. 2015 Apr 28;112(9):1461-70
pubmed: 25880007
Brain Behav Immun. 2013 Mar;30 Suppl:S32-40
pubmed: 22504092
Breast Cancer Res. 2018 Oct 1;20(1):116
pubmed: 30285809
Chemotherapy. 2014;60(5-6):288-9
pubmed: 25998892
Cancer Res. 2018 Jun 15;78(12):3233-3242
pubmed: 29661830
Breast Cancer Res Treat. 2013 Aug;140(3):567-75
pubmed: 23912960
Nature. 2019 May;569(7758):672-678
pubmed: 31092925
Cancer Epidemiol. 2013 Dec;37(6):881-5
pubmed: 24075077
Cell Death Discov. 2022 Mar 25;8(1):131
pubmed: 35338118
Cell. 2020 Apr 16;181(2):219-222
pubmed: 32302564
Brain Behav Immun. 2017 May;62:78-86
pubmed: 28212885
J Clin Invest. 2019 Mar 1;129(3):1030-1046
pubmed: 30688660
Int J Cancer. 2015 Dec 15;137(12):2815-24
pubmed: 26088878
Ann N Y Acad Sci. 2016 Jun;1373(1):5-12
pubmed: 26963792
Cancer Metastasis Rev. 2018 Dec;37(4):577-597
pubmed: 30465162
Brain Behav Immun. 2011 Jan;25(1):59-66
pubmed: 20674738
Apoptosis. 2002 Jun;7(3):247-60
pubmed: 11997669
Cancer Immunol Immunother. 2014 Jun;63(6):627-41
pubmed: 24682538
Clin Cancer Res. 2019 Apr 15;25(8):2621-2632
pubmed: 30504424
Brain Behav Immun. 2007 Nov;21(8):1038-49
pubmed: 17521871
Oncogene. 1998 May;16(20):2681-6
pubmed: 9632144
J Exp Clin Cancer Res. 2020 Aug 12;39(1):156
pubmed: 32787888
Mol Psychiatry. 2022 Aug;27(8):3214-3222
pubmed: 35668158
Lancet Oncol. 2022 Feb;23(2):e62-e74
pubmed: 35114133
J Clin Oncol. 2021 Nov 10;39(32):3583-3590
pubmed: 34357780
Brain Behav Immun. 2016 Oct;57:106-115
pubmed: 27321906
Cancer Res Treat. 2020 Jul;52(3):830-847
pubmed: 32138468
J Hepatol. 2014 Jun;60(6):1225-34
pubmed: 24607627
Clin Cancer Res. 2008 Dec 1;14(23):7593-603
pubmed: 19047084
Oncogene. 2021 Sep;40(35):5367-5378
pubmed: 34272474
Mol Cancer. 2011 Nov 26;10:146
pubmed: 22118662
Nat Commun. 2016 Mar 01;7:10634
pubmed: 26925549
Cell Death Differ. 2016 Aug;23(8):1271-82
pubmed: 26915296
J Clin Anesth. 2014 Mar;26(2):106-17
pubmed: 24480297
Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188665
pubmed: 34896258
J Clin Oncol. 2013 Jun 20;31(18):2265-72
pubmed: 23650417
Int J Biol Sci. 2021 Apr 10;17(6):1530-1537
pubmed: 33907516
Cancer Res. 2017 Oct 15;77(20):5639-5651
pubmed: 28819022
Angiogenesis. 2017 Nov;20(4):409-426
pubmed: 28660302
J Immunother Cancer. 2019 Mar 18;7(1):78
pubmed: 30885258
Brain Behav Immun. 2016 Aug;56:209-220
pubmed: 26944000
Pharmacol Ther. 2019 Jan;193:91-98
pubmed: 30048709
Eur J Cancer. 2006 Dec;42(18):3287-93
pubmed: 17070682
Nat Rev Drug Discov. 2018 Dec;17(12):887-904
pubmed: 30361552
Cell Rep. 2021 Mar 16;34(11):108821
pubmed: 33730592
Gynecol Oncol. 2016 Dec;143(3):521-525
pubmed: 27693123
Cell Death Dis. 2019 Oct 17;10(11):788
pubmed: 31624248
J Pathol. 2012 Jul;227(3):286-97
pubmed: 22553170
Immunity. 2015 Sep 15;43(3):435-49
pubmed: 26377897
Nature. 2016 Jan 21;529(7586):298-306
pubmed: 26791720
Cancer Immunol Res. 2022 Sep 1;10(9):1141-1154
pubmed: 35834791
Immunity. 2021 Jun 8;54(6):1219-1230.e7
pubmed: 33915109
J Clin Invest. 2010 May;120(5):1515-23
pubmed: 20389021
Cell Death Dis. 2021 Oct 23;12(11):987
pubmed: 34689156
Mol Cell. 2020 Jun 18;78(6):1019-1033
pubmed: 32559423
Cell Mol Immunol. 2018 May;15(5):458-469
pubmed: 29563615
Cell Death Dis. 2020 Aug 18;11(8):644
pubmed: 32811805
Radiother Oncol. 2020 May;146:126-135
pubmed: 32146258
Cancer Immunol Res. 2021 Jun;9(6):651-664
pubmed: 33762351
Oncogene. 2017 Mar;36(11):1525-1536
pubmed: 27641328
Cochrane Database Syst Rev. 2017 Jan 03;1:CD010802
pubmed: 28045199
Brain Behav Immun. 2008 Jul;22(5):717-26
pubmed: 18068331
J Cell Physiol. 2019 Mar;234(3):2013-2020
pubmed: 30240006
Nat Commun. 2018 Jul 13;9(1):2723
pubmed: 30006573
Cancer. 2011 Nov 15;117(22):5142-50
pubmed: 21538342
J Neurosci. 2018 Feb 28;38(9):2328-2340
pubmed: 29382712
J Clin Oncol. 2018 Oct 1;36(28):2872-2878
pubmed: 30125216
Cell Death Dis. 2020 Sep 15;11(9):761
pubmed: 32934214
Gynecol Oncol. 2021 Nov;163(2):342-347
pubmed: 34556331
Nat Commun. 2013;4:1403
pubmed: 23360994
Cell Rep. 2014 Apr 24;7(2):464-475
pubmed: 24703841
Brain Behav Immun. 2011 Feb;25(2):250-5
pubmed: 20955777
Urol Oncol. 2017 Jan;35(1):36.e1-36.e6
pubmed: 27687543
Semin Cancer Biol. 2020 Feb;60:166-180
pubmed: 31369817
Nat Commun. 2021 Sep 30;12(1):5725
pubmed: 34593796
J Clin Invest. 2013 Feb;123(2):874-86
pubmed: 23348742
Nutr Neurosci. 2017 Apr;20(3):161-171
pubmed: 26317148
Oncogene. 2016 Jan 7;35(1):47-58
pubmed: 25798840
Asian Pac J Cancer Prev. 2013;14(10):6109-14
pubmed: 24289634
Nature. 2022 Nov;611(7935):405-412
pubmed: 36323780
Cancer Immunol Immunother. 2019 Jan;68(1):11-22
pubmed: 30229289
Brain Behav Immun. 2009 Feb;23(2):176-83
pubmed: 18550328
Sci Rep. 2019 Aug 2;9(1):11257
pubmed: 31375708
Oncotarget. 2015 Feb 28;6(6):4266-73
pubmed: 25738355
J Clin Invest. 2021 Jun 1;131(11):
pubmed: 34060481
Brain Behav Immun. 2011 Mar;25(3):408-15
pubmed: 21047549
Front Pharmacol. 2021 Nov 29;12:714163
pubmed: 34912211
Gynecol Oncol. 2017 Jan;144(1):181-186
pubmed: 27863705
Radiat Res. 2019 Jun;191(6):585-589
pubmed: 31021732
Ann Oncol. 2014 Nov;25(11):2237-2243
pubmed: 25096607
Integr Cancer Ther. 2013 Jul;12(4):312-22
pubmed: 23142798
J Hematol Oncol. 2019 Sep 10;12(1):95
pubmed: 31500658
Oncoimmunology. 2017 Dec 21;7(3):e1405205
pubmed: 29399407
Oncologist. 2021 Apr;26(4):269-273
pubmed: 33465258
Clin Cancer Res. 2012 Mar 1;18(5):1201-6
pubmed: 22186256
Cancer Treat Rev. 2017 Jan;52:58-70
pubmed: 27894012
Ageing Res Rev. 2020 Sep;62:101125
pubmed: 32683038
Nat Med. 2006 Aug;12(8):939-44
pubmed: 16862152
J Autoimmun. 2018 Dec;95:77-99
pubmed: 30174217
J Pathol. 2018 Jan;244(1):49-60
pubmed: 28940209
J Immunol. 2013 Apr 1;190(7):3163-71
pubmed: 23420884
Brain Behav Immun. 2019 Aug;80:825-838
pubmed: 31125710
Mol Psychiatry. 2020 Dec;25(12):3186-3197
pubmed: 32820237
Brain Behav Immun. 2019 Aug;80:358-373
pubmed: 30953776
Breast Cancer Res. 2017 Mar 24;19(1):35
pubmed: 28340615
BMC Med. 2013 Sep 20;11:208
pubmed: 24229349
Acta Pharm Sin B. 2022 Jan;12(1):197-209
pubmed: 35127380
Cell Mol Immunol. 2020 Aug;17(8):807-821
pubmed: 32612154
Proc Natl Acad Sci U S A. 2012 May 1;109(18):7013-8
pubmed: 22509031
JCI Insight. 2017 Aug 17;2(16):
pubmed: 28814667
Cancer. 2015 Feb 1;121(3):476-84
pubmed: 25367403
Cancer Res. 2007 Nov 1;67(21):10389-96
pubmed: 17974982
J Clin Oncol. 1996 Oct;14(10):2709-12
pubmed: 8874331
J Exp Clin Cancer Res. 2014 Feb 20;33:21
pubmed: 24555849
Eur J Cancer. 2017 Feb;72:46-53
pubmed: 28024266
Science. 2017 Oct 20;358(6361):321-326
pubmed: 29051371
Oncotarget. 2010 Nov;1(7):628-38
pubmed: 21317458
Nat Commun. 2015 Mar 10;6:6426
pubmed: 25756236
Cancer Commun (Lond). 2021 Oct;41(10):1049-1070
pubmed: 34288568
Clin Cancer Res. 2021 Jan 1;27(1):87-95
pubmed: 33127652
Int J Cancer. 2021 Jul 15;149(2):460-472
pubmed: 33751565
Int J Cancer. 2011 Jul 15;129(2):407-16
pubmed: 21207410
Ann Oncol. 2013 May;24(5):1312-9
pubmed: 23300016
Sci Transl Med. 2017 Nov 8;9(415):
pubmed: 29118262
Cancer Treat Rev. 2010 Aug;36(5):377-83
pubmed: 20172656
BMC Med. 2015 Oct 29;13:275
pubmed: 26515383
Nature. 2020 Feb;578(7795):449-454
pubmed: 32051587
Cancer Res. 2004 Mar 1;64(5):1757-64
pubmed: 14996737
J Clin Oncol. 2016 Aug 20;34(24):2827-34
pubmed: 27247219
Int J Mol Sci. 2019 Nov 11;20(22):
pubmed: 31717935
J Immunol. 2010 Mar 1;184(5):2449-57
pubmed: 20124103
J Clin Oncol. 2014 Apr 1;32(10):1040-9
pubmed: 24470004
Circ Res. 2019 Oct 25;125(10):874-883
pubmed: 31550998
Cancer Res. 2017 Jul 1;77(13):3700-3707
pubmed: 28473530
Brain Behav Immun. 2017 Oct;65:140-149
pubmed: 28457810
Nature. 2011 Jun 08;475(7355):222-5
pubmed: 21654748
Gynecol Oncol. 2012 Nov;127(2):375-8
pubmed: 22819786
Cancer Immunol Res. 2021 Jul;9(7):765-778
pubmed: 33839688
Nat Rev Endocrinol. 2019 Sep;15(9):525-534
pubmed: 31249398
Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):329-37
pubmed: 26853341
Sci Rep. 2017 Jun 6;7(1):2911
pubmed: 28588274
Oncogene. 2018 May;37(22):2953-2966
pubmed: 29515233
BMC Med. 2015 Jun 08;13:121
pubmed: 26050790
Cancer. 2014 Apr 15;120(8):1178-86
pubmed: 24415516
Pancreatology. 2016 May-Jun;16(3):423-33
pubmed: 27083074
J Thorac Oncol. 2018 Nov;13(11):1771-1775
pubmed: 29935305
Nature. 2011 Aug 21;477(7364):349-53
pubmed: 21857681
Cancer Lett. 2009 Aug 28;281(2):151-61
pubmed: 19307055
BMB Rep. 2015 May;48(5):295-300
pubmed: 25748171
Cancer Res. 2019 Sep 1;79(17):4399-4411
pubmed: 31289134
Am J Cancer Res. 2017 Apr 01;7(4):946-954
pubmed: 28469966
Br J Clin Pharmacol. 2011 Jul;72(1):157-61
pubmed: 21453301
Brain Behav Immun. 2019 Oct;81:111-121
pubmed: 31176001
Oncogene. 2015 Jun;34(26):3402-12
pubmed: 25151968
Cell Rep. 2021 Oct 26;37(4):109883
pubmed: 34706232
Cancer Cell. 2017 Jan 9;31(1):21-34
pubmed: 27989802
BMC Complement Altern Med. 2013 Jan 19;13:16
pubmed: 23331546
J Clin Med. 2019 Apr 26;8(5):
pubmed: 31035526
Clin Cancer Res. 2006 Dec 1;12(23):6865-8
pubmed: 17145802
J Clin Oncol. 2011 Jul 1;29(19):2645-52
pubmed: 21632501
J Immunol. 2012 Jan 1;188(1):21-8
pubmed: 22187483
Obstet Gynecol. 2006 Dec;108(6):1381-7
pubmed: 17138770
Am J Cancer Res. 2020 May 01;10(5):1294-1307
pubmed: 32509380
Cancer Lett. 2017 Feb 28;387:61-68
pubmed: 26845449
Pharmacol Res. 2019 Mar;141:501-511
pubmed: 30682424
Nat Rev Clin Oncol. 2015 Apr;12(4):213-26
pubmed: 25601442
Nat Med. 2019 Sep;25(9):1428-1441
pubmed: 31501614
J Natl Cancer Inst. 2021 Jan 4;113(1):54-63
pubmed: 32239145
Nat Neurosci. 2019 Aug;22(8):1289-1305
pubmed: 31285612
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Nature. 2019 Mar;567(7749):540-544
pubmed: 30867597
Cancer Cell. 2018 Jan 8;33(1):75-90.e7
pubmed: 29249692
Psychol Med. 2010 Nov;40(11):1797-810
pubmed: 20085667
Nat Rev Cancer. 2015 Sep;15(9):563-72
pubmed: 26299593
J Exp Clin Cancer Res. 2019 May 2;38(1):181
pubmed: 31046799
Lancet Oncol. 2011 Feb;12(2):160-74
pubmed: 21251875
JAMA Oncol. 2018 Feb 08;4(2):e172908
pubmed: 28973254
Cancer Res. 2008 Jan 15;68(2):346-51
pubmed: 18199526
Brain Behav Immun. 2014 Mar;37:207-19
pubmed: 24333572
Acta Oncol. 2017 Dec;56(12):1665-1676
pubmed: 28686520
Gynecol Oncol. 2019 Sep;154(3):524-530
pubmed: 31353053
Nat Rev Immunol. 2018 Oct;18(10):635-647
pubmed: 30057419
Cell Mol Immunol. 2021 Apr;18(4):842-859
pubmed: 33139907
Cancers (Basel). 2019 Nov 25;11(12):
pubmed: 31769417
Cancer Immunol Res. 2018 Jan;6(1):98-109
pubmed: 29146881
Cancer. 2015 Oct 1;121(19):3444-51
pubmed: 26301456
J Clin Oncol. 2014 Apr 1;32(10):1058-65
pubmed: 24590636
Nat Rev Cancer. 2021 Dec;21(12):767-785
pubmed: 34508247
Breast Cancer Res. 2016 Aug 11;18(1):84
pubmed: 27515302
Mayo Clin Proc. 2013 Nov;88(11):1196-203
pubmed: 24182700
Signal Transduct Target Ther. 2020 Feb 7;5(1):8
pubmed: 32296030
Brain Behav Immun. 2021 Mar;93:368-383
pubmed: 33160090
Cancer. 2019 May 1;125(9):1417-1431
pubmed: 30768779