Oxytocin receptor is not required for social attachment in prairie voles.

Animals Male Female Receptors, Oxytocin / genetics Grassland Oxytocin Mammals Arvicolinae Social Behavior
CRISPR monogamy nursing oxytocin receptor pair-bonding parental behavior partner preference prairie vole social attachment

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
15 03 2023
Historique:
received: 12 07 2022
revised: 24 10 2022
accepted: 08 12 2022
pmc-release: 15 03 2024
pubmed: 29 1 2023
medline: 21 3 2023
entrez: 28 1 2023
Statut: ppublish

Résumé

Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines. Oxtr mutants displayed social attachment such that males and females showed a behavioral preference for their mating partners over a stranger of the opposite sex, even when assayed using different experimental setups. Mothers lacking Oxtr delivered viable pups, and parents displayed care for their young and raised them to the weanling stage. Together, our studies unexpectedly reveal that social attachment, parturition, and parental behavior can occur in the absence of Oxtr signaling in prairie voles.

Identifiants

DOI: 10.1016/j.neuron.2022.12.011 PMID: 36708707 PMC: PMC10150797
pubmed: 36708707
pii: S0896-6273(22)01084-4
doi: 10.1016/j.neuron.2022.12.011
pmc: PMC10150797
mid: NIHMS1866081
pii:
doi:

Substances chimiques

Receptors, Oxytocin 0
Oxytocin 50-56-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

787-796.e4

Subventions

Organisme : NIMH NIH HHS
ID : K08 MH107754
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH060482
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108319
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123513
Pays : United States
Organisme : NIMH NIH HHS
ID : DP1 MH099900
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests Dr. Nirao Shah is a member of the advisory board for Neuron.

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Auteurs

Kristen M Berendzen (KM)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.

Ruchira Sharma (R)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.

Maricruz Alvarado Mandujano (MA)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Yichao Wei (Y)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Forrest D Rogers (FD)

Department of Psychology, University of California, Davis, Davis, CA, USA.

Trenton C Simmons (TC)

Department of Psychology, University of California, Davis, Davis, CA, USA.

Adele M H Seelke (AMH)

Department of Psychology, University of California, Davis, Davis, CA, USA.

Jessica M Bond (JM)

Department of Psychology, University of California, Davis, Davis, CA, USA.

Rose Larios (R)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 95158, USA.

Nastacia L Goodwin (NL)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.

Michael Sherman (M)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.

Srinivas Parthasarthy (S)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Isidero Espineda (I)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Joseph R Knoedler (JR)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Annaliese Beery (A)

Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Karen L Bales (KL)

Department of Psychology, University of California, Davis, Davis, CA, USA; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA 95616, USA.

Nirao M Shah (NM)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: nirao@stanford.edu.

Devanand S Manoli (DS)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA. Electronic address: devanand.manoli@ucsf.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oxytocin receptor is not required for social...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteurs à l'ocytocine › Oxytocin receptor is not required for social...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Prairie › Oxytocin receptor is not required for social...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones post-hypophysaires › Ocytocine › Oxytocin receptor is not required for social...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Oxytocin receptor is not required for social...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Oxytocin receptor is not required for social...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › Oxytocin receptor is not required for social...