Design, synthesis and biological activity of hybrid antifungals derived from fluconazole and mebendazole.
Fluconazole
Hybrid molecules
Lanosterol 14α-demethylase (CYP51)
Mebendazole
Triazole antifungals
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Mar 2023
05 Mar 2023
Historique:
received:
03
01
2023
revised:
19
01
2023
accepted:
20
01
2023
pubmed:
30
1
2023
medline:
25
2
2023
entrez:
29
1
2023
Statut:
ppublish
Résumé
A novel series of triazole alcohol antifungals bearing a 5-benzoylbenzimidazol-2-ylthio side chain have been designed and synthesized as hybrids of fluconazole (a typical triazole antifungal) and mebendazole (an anthelmintic agent with antifungal activity). The title compounds were synthesized via the reaction of an appropriate oxirane and desired 2-mercaptobenzimidazole. Although there was possibility for formation of different N-substituted or S-substituted products, the structures of final compounds were assigned as thioether congeners by using
Identifiants
pubmed: 36709648
pii: S0223-5234(23)00061-2
doi: 10.1016/j.ejmech.2023.115146
pii:
doi:
Substances chimiques
Fluconazole
8VZV102JFY
Antifungal Agents
0
Mebendazole
81G6I5V05I
Triazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115146Informations de copyright
Copyright © 2023 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.