Microvascular inflammation in the absence of human leukocyte antigen-donor-specific antibody and C4d: An orphan category in Banff classification with cytotoxic T and natural killer cell infiltration.
antibody-mediated rejection
immune cell
immunohistochemistry
kidney biopsy
kidney transplantation
microvascular inflammation
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
01
06
2022
revised:
21
11
2022
accepted:
15
12
2022
medline:
10
4
2023
pubmed:
30
1
2023
entrez:
29
1
2023
Statut:
ppublish
Résumé
Isolated microvascular inflammation (iMVI) without HLA donor-specific antibodies or C4d deposition in peritubular capillaries remains an enigmatic phenotype that cannot be categorized as antibody-mediated rejection (ABMR) in recent Banff classifications. We included 221 kidney transplant recipients with biopsies with ABMR (n = 73), iMVI (n = 32), and normal (n = 116) diagnoses. We compared peripheral blood leukocyte distribution by flow cytometry and inflammatory infiltrates in kidney transplant biopsies among groups. Flow cytometry showed fewer lymphocytes and total, CD4
Identifiants
pubmed: 36710135
pii: S1600-6135(22)30223-X
doi: 10.1016/j.ajt.2022.12.018
pii:
doi:
Substances chimiques
Antibodies
0
HLA Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
464-474Informations de copyright
Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.