Studies in Zebrafish and Rat Models Support Dual Blockade of EP2 and EP4 (Prostaglandin E

Animals Rats Zebrafish / metabolism Receptors, Prostaglandin E, EP2 Subtype / genetics Albuminuria Dinoprostone Receptors, Prostaglandin E, EP4 Subtype / genetics Carrier Proteins Cyclooxygenase 2 / metabolism
albuminuria hypertension prostaglandin E2 rats zebrafish

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
04 2023
Historique:
pubmed: 31 1 2023
medline: 21 3 2023
entrez: 30 1 2023
Statut: ppublish

Résumé

Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. Upregulation of COX2 (cyclooxygenase 2) and prostaglandin E We conducted in vivo studies in a transgenic zebrafish model ( Stimulation of zebrafish embryos with PGE Our findings confirm a role of PGE

Sections du résumé

BACKGROUND
Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. Upregulation of COX2 (cyclooxygenase 2) and prostaglandin E
METHODS
We conducted in vivo studies in a transgenic zebrafish model (
RESULTS
Stimulation of zebrafish embryos with PGE
CONCLUSIONS
Our findings confirm a role of PGE

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.122.20392 PMID: 36715011
pubmed: 36715011
doi: 10.1161/HYPERTENSIONAHA.122.20392
doi:

Substances chimiques

Receptors, Prostaglandin E, EP2 Subtype 0
Dinoprostone K7Q1JQR04M
Receptors, Prostaglandin E, EP4 Subtype 0
Carrier Proteins 0
Cyclooxygenase 2 EC 1.14.99.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

771-782

Auteurs

Aikaterini Kourpa (A)

Institute of Clinical Pharmacology and Toxicology (A.K., A.S., E.M., D.K.-G., J.B., R.K.), Charité-Universitätsmedizin Berlin, Germany.
Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (A.K., M.B., B.P., S.K., T.G., T.N., D.P.).
ORCID: 0000-0002-9913-0299

Angela Schulz (A)

Institute of Clinical Pharmacology and Toxicology (A.K., A.S., E.M., D.K.-G., J.B., R.K.), Charité-Universitätsmedizin Berlin, Germany.

Eva Mangelsen (E)

Institute of Clinical Pharmacology and Toxicology (A.K., A.S., E.M., D.K.-G., J.B., R.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0003-2418-8805

Debora Kaiser-Graf (D)

Institute of Clinical Pharmacology and Toxicology (A.K., A.S., E.M., D.K.-G., J.B., R.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0002-5050-5539

Nils Koppers (N)

Genetic Epidemiology, Institute for Human Genetics, Westfälische Wilhelms University, Münster, Germany (N.K., M.S.).

Monika Stoll (M)

Genetic Epidemiology, Institute for Human Genetics, Westfälische Wilhelms University, Münster, Germany (N.K., M.S.).
ORCID: 0000-0002-2711-4281

Michael Rothe (M)

Lipidomix GmbH, Berlin, Germany (M.R.).

Michael Bader (M)

Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (A.K., M.B., B.P., S.K., T.G., T.N., D.P.).
German Center for Cardiovascular Research, Partner Site Berlin, Germany (M.B.).
Charité-Universitätsmedizin Berlin, Germany (M.B.).
Institute for Biology, University of Lübeck, Germany (M.B.).

Bettina Purfürst (B)

Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (A.K., M.B., B.P., S.K., T.G., T.N., D.P.).

Severine Kunz (S)

Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (A.K., M.B., B.P., S.K., T.G., T.N., D.P.).
ORCID: 0000-0002-0131-3506

Thomas Gladytz (T)

Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (A.K., M.B., B.P., S.K., T.G., T.N., D.P.).
ORCID: 0000-0003-1072-0098

Thoralf Niendorf (T)

Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (A.K., M.B., B.P., S.K., T.G., T.N., D.P.).

Sebastian Bachmann (S)

Institute of Vegetative Anatomy (S.B.), Charité-Universitätsmedizin Berlin, Germany.

Kerim Mutig (K)

Institute of Translational Physiology (K.M.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0001-9006-5112

Juliane Bolbrinker (J)

Institute of Clinical Pharmacology and Toxicology (A.K., A.S., E.M., D.K.-G., J.B., R.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0002-0812-8549

Daniela Panáková (D)

Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (A.K., M.B., B.P., S.K., T.G., T.N., D.P.).
ORCID: 0000-0002-8739-6225

Reinhold Kreutz (R)

Institute of Clinical Pharmacology and Toxicology (A.K., A.S., E.M., D.K.-G., J.B., R.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0002-4818-211X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteur prostaglandine › Récepteur prostaglandine E › Sous-type EP2 des récepteurs des prostaglandines E › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations urologiques › Protéinurie › Albuminurie › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteur prostaglandine › Récepteur prostaglandine E › Sous-type EP4 des récepteurs des prostaglandines E › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Studies in Zebrafish and Rat Models Support...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 2 › Studies in Zebrafish and Rat Models Support...