Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines.
1,8-naphthalimides
Carborane
anticancer activity
intercalation
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
1
2
2023
Statut:
ppublish
Résumé
The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesised via amidation and reductive amination reactions, and their calf thymus DNA (ct-DNA)-binding properties were investigated using circular dichroism, UV-vis spectroscopy, and thermal denaturation. Results showed that conjugates
Identifiants
pubmed: 36715272
doi: 10.1080/14756366.2023.2171028
pmc: PMC9888480
doi:
Substances chimiques
Intercalating Agents
0
Antineoplastic Agents
0
Naphthalimides
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2171028Références
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