Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease.
gut microbiota
insulin resistance
liver fat
metabolomics
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 02 2023
28 02 2023
Historique:
pubmed:
31
1
2023
medline:
3
3
2023
entrez:
30
1
2023
Statut:
ppublish
Résumé
Numerous studies have described specific metabolites as biomarkers of severe liver diseases, but very few have measured gut microbiota (GM)-produced metabolites in fatty liver disease. We aimed at finding GM signatures and metabolite markers in plasma and feces related to high liver fat content. Based on imaging, we divided study participants into low (<5%, LF,
Identifiants
pubmed: 36715540
doi: 10.1128/mbio.02663-22
pmc: PMC9973343
doi:
Substances chimiques
Lysine
K3Z4F929H6
Histidine
4QD397987E
RNA, Ribosomal, 16S
0
Caffeine
3G6A5W338E
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0266322Références
Gut. 2018 Oct;67(10):1881-1891
pubmed: 28774887
Hepatology. 2013 Jun;57(6):2525-31
pubmed: 23390127
Metabolism. 2016 Aug;65(8):1109-23
pubmed: 27237577
Hepatol Commun. 2019 Aug 13;3(10):1311-1321
pubmed: 31592078
Curr Drug Metab. 2009 May;10(4):329-38
pubmed: 19519341
Cell Metab. 2012 May 2;15(5):665-74
pubmed: 22560219
PLoS Biol. 2016 Aug 19;14(8):e1002533
pubmed: 27541692
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Diabetes Care. 1998 Dec;21(12):2191-2
pubmed: 9839117
Metabolism. 2019 Mar;92:82-97
pubmed: 30502373
FEMS Microbiol Ecol. 2015 Feb;91(2):1-9
pubmed: 25764541
Int J Mol Sci. 2021 Mar 30;22(7):
pubmed: 33808194
Klin Wochenschr. 1989 Jan 4;67(1):6-15
pubmed: 2921843
Nat Commun. 2020 Oct 5;11(1):4982
pubmed: 33020474
ISME J. 2017 Jul;11(7):1667-1679
pubmed: 28375212
Hepatology. 2016 Jul;64(1):73-84
pubmed: 26707365
Gastroenterol Res Pract. 2010;2010:
pubmed: 20706692
Gut Microbes. 2020 May 3;11(3):569-580
pubmed: 31696774
Metabolism. 2019 Dec;101:154005
pubmed: 31711876
Diabetes Care. 2006 Aug;29(8):1845-50
pubmed: 16873790
United European Gastroenterol J. 2018 Dec;6(10):1496-1507
pubmed: 30574320
J Hepatol. 2015 Apr;62(1 Suppl):S47-64
pubmed: 25920090
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Feb;69(2 Pt 2):026113
pubmed: 14995526
J Natl Cancer Inst. 2020 Mar 1;112(3):286-294
pubmed: 31168595
Clin Pharmacol Ther. 1995 Dec;58(6):684-91
pubmed: 8529334
Nutrients. 2017 May 11;9(5):
pubmed: 28492501
Liver Res. 2020 Jun;4(2):47-63
pubmed: 34290896
Hepatology. 2013 Jul;58(1):120-7
pubmed: 23401313
Hepatol Commun. 2022 Aug;6(8):1962-1974
pubmed: 35344283
Mol Cell. 2020 May 21;78(4):584-596
pubmed: 32234490
Metabolites. 2020 Mar 31;10(4):
pubmed: 32244411
Diabetes Care. 2007 May;30(5):1212-8
pubmed: 17277038
PLoS One. 2016 May 20;11(5):e0151829
pubmed: 27203081
Diabetologia. 2013 Oct;56(10):2266-74
pubmed: 23824212
Hepatology. 2017 Jan;65(1):350-362
pubmed: 27358174
Int J Obes (Lond). 2015 Feb;39(2):279-87
pubmed: 24675715
J Hepatol. 2014 Jul;61(1):132-8
pubmed: 24613361
Gastroenterology. 2007 Aug;133(2):496-506
pubmed: 17681171
Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G608-G614
pubmed: 30869529
Nat Rev Dis Primers. 2015 Dec 17;1:15080
pubmed: 27188459
Pharmaceuticals (Basel). 2020 Aug 29;13(9):
pubmed: 32872474
Clin Nutr. 2021 May;40(5):3250-3262
pubmed: 33190988
World J Gastroenterol. 2017 Apr 21;23(15):2771-2784
pubmed: 28487615
Hepatol Commun. 2018 May 04;2(7):807-820
pubmed: 30027139
Hepatology. 2019 Jan;69(1):107-120
pubmed: 29665135
Curr Protoc Toxicol. 2004 Jun;Chapter 4:Unit4.13
pubmed: 20945304
Dig Dis. 2010;28(1):203-9
pubmed: 20460912
Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15430-5
pubmed: 19706383
Drug Metab Dispos. 2009 Oct;37(10):2087-94
pubmed: 19651758
Clin Gastroenterol Hepatol. 2016 Oct;14(10):1463-1472.e6
pubmed: 27317851
Hepatology. 2016 Mar;63(3):764-75
pubmed: 26600078
Nat Rev Endocrinol. 2019 May;15(5):261-273
pubmed: 30670819
Nutrients. 2020 Oct 22;12(11):
pubmed: 33105554
J Clin Endocrinol Metab. 2015 Jun;100(6):2231-8
pubmed: 25885947