Differences in IgG autoantibody Fab glycosylation across autoimmune diseases.

Humans Autoimmune Diseases Autoantibodies Myasthenia Gravis Arthritis, Rheumatoid Immunoglobulin G Lupus Erythematosus, Systemic Autoantigens
Autoimmune diseases Fab glycosylation IgG autoantibodies

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
06 2023
Historique:
received: 10 03 2022
revised: 12 10 2022
accepted: 14 10 2022
medline: 9 6 2023
pubmed: 31 1 2023
entrez: 30 1 2023
Statut: ppublish

Résumé

Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases. To study whether elevated Fab glycosylation is a common feature of autoimmunity, this study investigated Fab glycosylation levels on serum IgG and its subclasses for autoantibodies associated with a range of different B cell-mediated autoimmune diseases, including rheumatoid arthritis, myasthenia gravis subtypes, pemphigus vulgaris, antineutrophil cytoplasmic antibody-associated vasculitis, systemic lupus erythematosus, anti-glomerular basement membrane glomerulonephritis, thrombotic thrombocytopenic purpura, and Guillain-Barré syndrome. The level of Fab glycosylated IgG antibodies was assessed by lectin affinity chromatography and autoantigen-specific immunoassays. In 6 of 10 autoantibody responses, in 5 of 8 diseases, the investigators found increased levels of Fab glycosylation on IgG autoantibodies that varied from 86% in rheumatoid arthritis to 26% in systemic lupus erythematosus. Elevated autoantibody Fab glycosylation was not restricted to IgG These data indicate that in chronic but not acute B cell-mediated autoimmune diseases, disease-specific autoantibodies are enriched for Fab glycans.

Sections du résumé

BACKGROUND
Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases.
OBJECTIVES
To study whether elevated Fab glycosylation is a common feature of autoimmunity, this study investigated Fab glycosylation levels on serum IgG and its subclasses for autoantibodies associated with a range of different B cell-mediated autoimmune diseases, including rheumatoid arthritis, myasthenia gravis subtypes, pemphigus vulgaris, antineutrophil cytoplasmic antibody-associated vasculitis, systemic lupus erythematosus, anti-glomerular basement membrane glomerulonephritis, thrombotic thrombocytopenic purpura, and Guillain-Barré syndrome.
METHODS
The level of Fab glycosylated IgG antibodies was assessed by lectin affinity chromatography and autoantigen-specific immunoassays.
RESULTS
In 6 of 10 autoantibody responses, in 5 of 8 diseases, the investigators found increased levels of Fab glycosylation on IgG autoantibodies that varied from 86% in rheumatoid arthritis to 26% in systemic lupus erythematosus. Elevated autoantibody Fab glycosylation was not restricted to IgG
CONCLUSIONS
These data indicate that in chronic but not acute B cell-mediated autoimmune diseases, disease-specific autoantibodies are enriched for Fab glycans.

Identifiants

DOI: 10.1016/j.jaci.2022.10.035 PMID: 36716825
pubmed: 36716825
pii: S0091-6749(23)00091-X
doi: 10.1016/j.jaci.2022.10.035
pii:
doi:

Substances chimiques

Autoantibodies 0
Immunoglobulin G 0
Autoantigens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1646-1654

Informations de copyright

Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Auteurs

Jana Koers (J)

Department of Immunopathology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Rocco Sciarrillo (R)

Department of Immunopathology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Ninotska I L Derksen (NIL)

Department of Immunopathology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Esther M Vletter (EM)

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Yvonne E Fillié-Grijpma (YE)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Elisabeth Raveling-Eelsing (E)

Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

Nuno A G Graça (NAG)

Department of Molecular Hematology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Thiemo Leijser (T)

Department of Immunopathology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Hendri H Pas (HH)

Centre for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

L Laura van Nijen-Vos (L)

Centre for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Maaike V J Braham (MVJ)

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Anne-Marie Buisman (AM)

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Jan de Jong (J)

Sanquin Diagnostic Services, Amsterdam, The Netherlands.

Angela I Schriek (AI)

Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands.

Anne P Tio-Gillen (AP)

Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Y K Onno Teng (YKO)

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

Maurice Steenhuis (M)

Department of Immunopathology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Francis H Swaneveld (FH)

Department of Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.

Steven W de Taeye (SW)

Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands.

Marit J van Gils (MJ)

Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands.

Jan J G M Verschuuren (JJGM)

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Bram Rutgers (B)

Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

Peter Heeringa (P)

Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

Barbara Horváth (B)

Centre for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Bart C Jacobs (BC)

Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Karina de Leeuw (K)

Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

Casper F M Franssen (CFM)

Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

Agnès Veyradier (A)

Service d'Hématologie biologique, Hôpital Lariboisière and EA-3518 Institut de Recherche Saint Louis, Assistance Publique-Hôpitaux de Paris, Université de Paris, France; Centre de Référence des Microangiopathies Thrombotiques, Hôpital Saint-Antoine, AP-HP, Paris, France.

Paul Coppo (P)

Centre de Référence des Microangiopathies Thrombotiques, Hôpital Saint-Antoine, AP-HP, Paris, France; Service d'Hématologie, Hôpital Saint-Antoine, AP-HP, Paris, France; Faculté de médecine, Sorbonne Université, UPMC Univ Paris, Paris, France.

Kyra A Gelderman (KA)

Sanquin Diagnostic Services, Amsterdam, The Netherlands.

S Marieke van Ham (S)

Department of Immunopathology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

Cécile A C M van Els (CACM)

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Diane van der Woude (D)

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Ruth Huizinga (R)

Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands.

Maartje G Huijbers (MG)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Taco W Kuijpers (TW)

Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, The Netherlands; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Rene E M Toes (REM)

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Nicolaas A Bos (NA)

Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

Theo Rispens (T)

Department of Immunopathology, Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: t.rispens@sanquin.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Differences in IgG autoantibody Fab...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Differences in IgG autoantibody Fab...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Differences in IgG autoantibody Fab...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Myasthénie › Differences in IgG autoantibody Fab...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Differences in IgG autoantibody Fab...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Differences in IgG autoantibody Fab...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Differences in IgG autoantibody Fab...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Differences in IgG autoantibody Fab...