The von Hippel-Lindau Tumor Suppressor Gene Mutations Modulate Lipocalin-2 Expression in Ferroptotic-Inflammatory Pathways.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
09
2022
revised:
26
10
2022
accepted:
24
11
2022
entrez:
31
1
2023
pubmed:
1
2
2023
medline:
2
2
2023
Statut:
epublish
Résumé
A previous study of an animal model with tumor suppressor gene von Hippel-Lindau (VHL) conditional knockdown suggested that tissue inflammation and fibrosis play important roles in the development of clear-cell renal cell carcinoma (ccRCC), which is consistent with the epidemiological evidence linking inflammatory kidney disease and renal cancer. Ferroptosis and inflammation have been linked in a recent study, but the exact mechanism remains unclear. This study is aimed at investigating the mechanism of lipocalin-2- (LCN-2-) mediated ferroptosis and inflammation in
Identifiants
pubmed: 36718277
doi: 10.1155/2023/7736638
pmc: PMC9884170
doi:
Substances chimiques
Lipocalin-2
0
Reactive Oxygen Species
0
Von Hippel-Lindau Tumor Suppressor Protein
EC 2.3.2.27
VHL protein, mouse
EC 6.3.2.-
Lcn2 protein, mouse
126469-30-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7736638Informations de copyright
Copyright © 2023 Chan-Yen Kuo et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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