Neurodevelopmental disorders (NDD) without boundaries: research and interventions beyond classifications.
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pubmed:
1
2
2023
medline:
25
3
2023
entrez:
31
1
2023
Statut:
ppublish
Résumé
On June 2022, the 2nd Webinar "Neurodevelopmental Disorders (NDD) without boundaries took place at the Imagine Institute in Paris and was broadcasted live and in replay. The aim of this webinar is to address NDD in a dimensional rather than in a categorical approach. Several speakers were invited to present their researches on the subject. Classifications in NDD were discussed: irritability in NDD, involvement of the immune system in neurodevelopment, nutrition and gut microbiota modulate brain inflammation and neurodevelopment, co-occurring conditions in autistic adolescents and adults without intellectual disability. Classifications in psychiatric disorders were asked: mapping the effect of genes on cognition and autism risk, epigenetics and symptomatic trajectory in neurodevelopmental disorders, the autism-schizophrenia continuum in two examples: minor neurological signs and EEG microstates, the cerebellum in schizophrenia and autism: from imaging to intervention perspectives. Both genetic and environmental factors, along with clinical and imaging features, argue toward a continnum between NDD but also with adult psychiatric presentations. This new paradigm could modify the therapeutic strategy, with the development of large-spectrum treatments or new psychotherapies addressing co-occuring symptoms. The complexity and the heterogeneity of NDD apply well to the next scientific and political challenges: developing international convergence to push back the frontiers of our knowledge. This article is a summary of the 2nd webinar "Neurodevelopmental Disorders (NDD) without boundaries: research and interventions beyond classifications" sponsored by the French National Academy of Medicine, the autism and neurodevelopmental disorders scientific interest group (GIS), the International Research Network Dev-O-Psy and the French Institute of Psychiatry (GDR3557). Oral presentations are available as a replay on the following website (in French): https://autisme-neurodev.org/evenements/2022/04/12/tnd-sans-frontieres-la-recherche-et-les-interventions-au-dela-des-classifications/ .
Identifiants
pubmed: 36719463
doi: 10.1007/s00702-023-02586-w
pii: 10.1007/s00702-023-02586-w
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
473-479Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
Références
Andreasen NC, Flaum M, Swayze V, O’Leary DS, Alliger R, Cohen G, Ehrhardt J, Yuh WT (1993) Intelligence and brain structure in normal individuals. Am J Psychiatry 150:130–134. https://doi.org/10.1176/ajp.150.1.130
doi: 10.1176/ajp.150.1.130
pubmed: 8417555
Brady RO, Gonsalvez I, Lee I, Öngür D, Seidman LJ, Schmahmann JD, Eack SM, Keshavan MS, Pascual-Leone A, Halko MA (2019) Cerebellar-prefrontal network connectivity and negative symptoms in schizophrenia. Am J Psychiatry 176:512–520. https://doi.org/10.1176/appi.ajp.2018.18040429
doi: 10.1176/appi.ajp.2018.18040429
pubmed: 30696271
pmcid: 6760327
Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L et al (2018) Analysis of shared heritability in common disorders of the brain. Science 360(6395):8757. https://doi.org/10.1126/science.aap8757
doi: 10.1126/science.aap8757
Brotman MA, Kircanski K, Leibenluft E (2017) Irritability in children and adolescents. Annual Rev Clin Psychol 13:317–341. https://doi.org/10.1146/annurev-clinpsy-032816-044941
doi: 10.1146/annurev-clinpsy-032816-044941
Collins RL, Glessner JT, Porcu E, Niestroj L-M, Ulirsch J, Kellaris G, Howrigan DP et al (2021) A cross-disorder dosage sensitivity map of the human genome. medRxiv. https://doi.org/10.1101/2021.01.26.21250098
doi: 10.1101/2021.01.26.21250098
pubmed: 33791717
pmcid: 8010749
de la Cruz F, Lorena ES, McGough JJ, Halperin JM, Arnold LE, Stringaris A (2015) Treatment of children with attention-deficit/hyperactivity disorder (ADHD) and irritability: results from the multimodal treatment study of children with ADHD (MTA). J Am Acad Child Adolescent Psychiatry 54:62–703. https://doi.org/10.1016/j.jaac.2014.10.006
doi: 10.1016/j.jaac.2014.10.006
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu; Cross-Disorder Group of the Psychiatric Genomics Consortium.Cell. 2019 Dec 12;179(7):1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020
Graziano PA, Garcia A (2016) Attention-deficit hyperactivity disorder and children’s emotion dysregulation: a meta-analysis. Clin Psychol Rev 46:106–123. https://doi.org/10.1016/j.cpr.2016.04.011
doi: 10.1016/j.cpr.2016.04.011
pubmed: 27180913
Hawes MT, Carlson GA, Finsaas MC, Olino TM, Seely JR, Klein DN (2020) Dimensions of irritability in adolescents: longitudinal associations with psychopathology in adulthood. Psychol Med 50(16):2759–2767. https://doi.org/10.1017/s0033291719002903
doi: 10.1017/s0033291719002903
pubmed: 31637980
« Human and preclinical studies of the host–gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. Gut (2022). https://gut.bmj.com/content/70/11/2105.abstract .
Jacquemont S, Huguet G, Klein M, Chawner SJRA, Donald KA, van den Bree MBM, Sebat J et al (2022) Genes to mental health (G2MH): a framework to map the combined effects of rare and common variants on dimensions of cognition and psychopathology. Am J Psychiatry 179:189–203. https://doi.org/10.1176/appi.ajp.2021.21040432
Jonas RK, Montojo CA, Bearden CE.Biol Psychiatry. 2014 Mar 1;75(5):351-60. https://doi.org/10.1016/j.biopsych.2013.07.019
Labrousse VF, Leyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S et al (2018) Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun 73:427–440. https://doi.org/10.1016/j.bbi.2018.06.004
doi: 10.1016/j.bbi.2018.06.004
pubmed: 29879442
Laidi C, d'Albis MA, Wessa M, Linke J, Phillips ML, Delavest M, Bellivier F, Versace A, Almeida J, Sarrazin S, Poupon C, Le Dudal K, Daban C, Hamdani N, Leboyer M, Houenou J. Acta Psychiatr Scand. 2015 Mar;131(3):223-33. https://doi.org/10.1111/acps.12363
Laidi C, Floris DL, Tillmann J, Elandaloussi Y, Zabihi M, Charman T, Wolfers T, Durston S, Moessnang C, Dell'Acqua F, Ecker C, Loth E, Murphy D, Baron-Cohen S, Buitelaar JK, Marquand AF, Beckmann CF, Frouin V, Leboyer M, Duchesnay E, Coupé P, Houenou J; EU-AIMS LEAP Group.Biol Psychiatry. 2022 Oct 15;92(8):674-682. https://doi.org/10.1016/j.biopsych.2022.05.020.
Laidi C, Boisgontier J, de Pierrefeu A, Duchesnay E, Hotier S, d’Albis M-A, Delorme R et al (2019) Decreased cortical thickness in the anterior cingulate cortex in adults with autism. J Autism Develop Disord 49:1402–1409. https://doi.org/10.1007/s10803-018-3807-3
doi: 10.1007/s10803-018-3807-3
Leyrolle Q, Cserjesi R, Mulders MDGH, Zamariola G, Hiel S, Gianfrancesco MA, Portheault D et al (2021) Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trial. Brain Behav Immun 94:289–298. https://doi.org/10.1016/j.bbi.2021.01.014
doi: 10.1016/j.bbi.2021.01.014
pubmed: 33515740
Leyrolle Q, Decoeur F, Dejean C, Brière G, Leon S, Bakoyiannis I, Baroux E et al (2022) N-3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development. Glia 70(1):50–70
doi: 10.1002/glia.24088
pubmed: 34519378
Ma B, Kircanski K, Stringaris A, Pine DS, Leibenluft E (2017) Irritability in youths: a translational mode. Am J Psychiatry. https://doi.org/10.1176/appi.ajp.2016.16070839
doi: 10.1176/appi.ajp.2016.16070839
Madore C, Leyrolle Q, Morel L, Rossitto M, Greenhalgh AD, Delpech JC, Martinat M, Bosch-Bouju C, Bourel J, Rani B, Lacabanne C, Thomazeau A, Hopperton KE, Beccari S, Sere A, Aubert A, De Smedt-Peyrusse V, Lecours C, Bisht K, Fourgeaud L, Gregoire S, Bretillon L, Acar N, Grant NJ, Badaut J, Gressens P, Sierra A, Butovsky O, Tremblay ME, Bazinet RP, Joffre C, Nadjar A, Layé S.Nat Commun. 2020 Nov 30;11(1):6133. https://doi.org/10.1038/s41467-020-19861-z
Michel CM, Koenig T (2018) EEG microstates as a tool for studying the temporal dynamics of whole-brain neuronal networks: a review. Neuroimage 180:577–593. https://doi.org/10.1016/j.neuroimage.2017.11.062
doi: 10.1016/j.neuroimage.2017.11.062
pubmed: 29196270
Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, Wei-Li W et al (2022) A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature 602(7898):647–653. https://doi.org/10.1038/s41586-022-04396-8
doi: 10.1038/s41586-022-04396-8
pubmed: 35165440
pmcid: 9170029
Salazar de Pablo G, Pascual-Sánchez A, Panchal U, Clark B, Krebs G.J Affect Disord. 2023 Feb 1;322:289-299. https://doi.org/10.1016/j.jad.2022.11.007
Stringaris A, Vidal-Ribas P, Brotman MA, Leibenluft E (2018) Practitioner review: definition, recognition, and treatment challenges of irritability in young people. J Child Psychol Psychiatry All Discip 59(7):721–739. https://doi.org/10.1111/jcpp.12823
doi: 10.1111/jcpp.12823
Sydnor VJ, Larsen B, Bassett DS, Alexander-Bloch A, Fair DA, Liston C, Mackey AP et al (2021) Neurodevelopment of the association cortices: patterns, mechanisms, and implications for psychopathology. Neuron 109(18):2820–2846. https://doi.org/10.1016/j.neuron.2021.06.016
doi: 10.1016/j.neuron.2021.06.016
pubmed: 34270921
pmcid: 8448958
Towbin K, Vidal-Ribas P, Brotman MA, Pickles A, Miller KV, Kaiser A, Vitale AD et al (2020) A double-blind randomized placebo-controlled trial of citalopram adjunctive to stimulant medication in youth with chronic severe irritability. J Am Acad Child Adolesc Psychiatry 59(3):350–361. https://doi.org/10.1016/j.jaac.2019.05.015
doi: 10.1016/j.jaac.2019.05.015
pubmed: 31128268
Van Overwalle F, D’aes T, Mariën P (2015) Social cognition and the cerebellum: a meta-analytic connectivity analysis. Human Brain Map 36(12):5137–5154. https://doi.org/10.1002/hbm.23002
doi: 10.1002/hbm.23002
Vidal-Ribas P, Brotman MA, Valdivieso I, Leibenluft E, Stringaris A (2016) The status of irritability in psychiatry: a conceptual and quantitative review. J Am Acad Child Adolesc Psychiatry 55:556–570. https://doi.org/10.1016/j.jaac.2016.04.014
doi: 10.1016/j.jaac.2016.04.014
pubmed: 27343883
pmcid: 4927461
Vuong HE, Pronovost GN, Williams DW, Coley EJL, Siegler EL, Qiu A, Kazantsev M, Wilson CJ, Rendon T, Hsiao EY (2020) The maternal microbiome modulates fetal neurodevelopment in mice. Nature 586:281–286. https://doi.org/10.1038/s41586-020-2745-3
doi: 10.1038/s41586-020-2745-3
pubmed: 32968276
pmcid: 7554197
Writing Committee for the Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder, Major Depressive Disorder, Obsessive-Compulsive Disorder, and Schizophrenia ENIGMA Working Groups, Yash Patel, et al. « Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders ». JAMA Psychiatry 78, n