Increased Metallothionein-1 Associated with Gout Activity and Tophi.

Humans Interleukin-6 / genetics Leukocytes, Mononuclear / metabolism C-Reactive Protein / metabolism Metallothionein / genetics Gout / genetics Cytokines / metabolism
Gout metallothionein-1 peripheral blood mononuclear cell tophi

Journal

Immunological investigations
ISSN: 1532-4311
Titre abrégé: Immunol Invest
Pays: England
ID NLM: 8504629

Informations de publication

Date de publication:
Apr 2023
Historique:
medline: 4 4 2023
pubmed: 1 2 2023
entrez: 31 1 2023
Statut: ppublish

Résumé

Gout is a chronic self-limiting inflammatory arthritis. An increase in metallothionein-1 (MT-1) has been reported in rheumatoid arthritis and osteoarthritis, and it attenuates inflammation and the pathology of diseases. This study aims to detect MT-1 levels in patients with gout and to explore its correlation with disease activity, clinical indexes, and inflammatory cytokines. The expression of MT-1 messenger RNAs (mRNAs) and protein levels in patients with gout were measured using real-time polymerase chain reaction and enzyme-linked immunosorbent assay. Correlations between MT-1 and clinical indexes or inflammatory mediators were analyzed using Spearman's correlation test. Compared with healthy controls (HCs, The higher levels of MT-1 were found in patients with gout, which were correlated with disease activity and gout related pro-inflammatory cytokines. Indicating MT-1 may serve as a new marker for predicting disease activity.

Sections du résumé

BACKGROUND AND AIMS UNASSIGNED
Gout is a chronic self-limiting inflammatory arthritis. An increase in metallothionein-1 (MT-1) has been reported in rheumatoid arthritis and osteoarthritis, and it attenuates inflammation and the pathology of diseases. This study aims to detect MT-1 levels in patients with gout and to explore its correlation with disease activity, clinical indexes, and inflammatory cytokines.
METHODS UNASSIGNED
The expression of MT-1 messenger RNAs (mRNAs) and protein levels in patients with gout were measured using real-time polymerase chain reaction and enzyme-linked immunosorbent assay. Correlations between MT-1 and clinical indexes or inflammatory mediators were analyzed using Spearman's correlation test.
RESULTS UNASSIGNED
Compared with healthy controls (HCs,
CONCLUSION UNASSIGNED
The higher levels of MT-1 were found in patients with gout, which were correlated with disease activity and gout related pro-inflammatory cytokines. Indicating MT-1 may serve as a new marker for predicting disease activity.

Identifiants

DOI: 10.1080/08820139.2023.2173078 PMID: 36719801
pubmed: 36719801
doi: 10.1080/08820139.2023.2173078
doi:

Substances chimiques

Interleukin-6 0
C-Reactive Protein 9007-41-4
Metallothionein 9038-94-2
Cytokines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

319-331

Auteurs

Yanmei Ma (Y)

Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Biological Therapy Institute, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Zhihua Yin (Z)

Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Hanying Dai (H)

Biological Therapy Institute, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen, China.

Dandan Wu (D)

Biological Therapy Institute, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen, China.

Junxiao Cong (J)

Biological Therapy Institute, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Xinmin Huang (X)

Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Xinpeng Chen (X)

Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Linghua Zou (L)

Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Zhizhong Ye (Z)

Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

Zhong Huang (Z)

Biological Therapy Institute, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen, China.
Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased Metallothionein-1 Associated with...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Increased Metallothionein-1 Associated with...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Increased Metallothionein-1 Associated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéine C-réactive › Increased Metallothionein-1 Associated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Métallothionéine › Increased Metallothionein-1 Associated with...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme de la purine et de la pyrimidine › Goutte › Increased Metallothionein-1 Associated with...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Increased Metallothionein-1 Associated with...