Corpus callosum-fastigium and tectal lengths in late-onset small fetuses.
FGR
SGA
corpus callosum
fastigium
fetal growth restriction
intrauterine growth restriction
midbrain
neurosonography
small-for-gestational age
tectal length
Journal
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
ISSN: 1469-0705
Titre abrégé: Ultrasound Obstet Gynecol
Pays: England
ID NLM: 9108340
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
revised:
19
11
2022
received:
29
04
2022
accepted:
06
12
2022
medline:
23
10
2023
pubmed:
2
2
2023
entrez:
1
2
2023
Statut:
ppublish
Résumé
To investigate measurements on neurosonography of midbrain morphology, including corpus callosum-fastigium length and tectal length, in late-onset small fetuses subclassified as small-for-gestational-age (SGA) or growth-restricted (FGR). This was a case-control study of consecutive singleton pregnancies delivered at term at a single center between January 2019 and July 2021, including those with late-onset smallness (estimated fetal weight (EFW) < 10 A total of 70 fetuses with late-onset smallness (29 with SGA and 41 with FGR) and 70 controls were included. Compared with controls, small fetuses showed significantly shorter corpus callosum-fastigium length (median (interquartile range), 44.7 (43.3-46.8) mm vs 43.7 (42.4-45.5) mm, P < 0.001) and tectal length (mean ± SD, 10.5 ± 0.9 vs 9.6 ± 1.0 mm, P < 0.001). These changes were more prominent in FGR fetuses, with a linear trend across groups according to severity of smallness. Corpus callosum-fastigium length and tectal length measurements showed excellent intra- and interobserver reliability. Small fetuses exhibited shorter corpus callosum-fastigium length and tectal length compared with controls, and these differences were more pronounced in fetuses with more severe smallness. These findings illustrate the potential value of midbrain measurements assessed on neurosonography as biomarkers for brain development in a high-risk population. However, further studies correlating these parameters with postnatal functional tests and follow-up are needed. © 2023 International Society of Ultrasound in Obstetrics and Gynecology.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-233Subventions
Organisme : Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK)
Organisme : Departament de Salut
ID : SLT008/18/00156
Organisme : ICREA Acadèmia Distinguished Professorship awarded to Carles Escera
Organisme : MDM-2017-0729-18-2 María de Maeztu Center of Excellence
ID : MCIN/AEI/10.13039/501100011033
Organisme : Spanish Ministry of Science and Innovation PGC2018-094765-B-I00 project (FEDER "Una manera de hacer Europa")
Informations de copyright
© 2023 International Society of Ultrasound in Obstetrics and Gynecology.
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