Xanthene-Based Nitric Oxide-Responsive Nanosensor for Photoacoustic Imaging in the SWIR Window.
D-A-D Xanthene Dyes
Drug-Induced Liver Injury
Nitric Oxide
Photoacoustic Imaging
SWIR
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
20 03 2023
20 03 2023
Historique:
received:
10
10
2022
pubmed:
2
2
2023
medline:
16
3
2023
entrez:
1
2
2023
Statut:
ppublish
Résumé
Shortwave infrared (SWIR) dyes are characterized by their ability to absorb light from 900 to 1400 nm, which is ideal for deep tissue imaging owing to minimized light scattering and interference from endogenous pigments. An approach to access such molecules is to tune the photophysical properties of known near-infrared dyes. Herein, we report the development of a series of easily accessible (three steps) SWIR xanthene dyes based on a dibenzazepine donor conjugated to thiophene (SCR-1), thienothiophene (SCR-2), or bithiophene (SCR-3). We leverage the fact that SCR-1 undergoes a bathochromic shift when aggregated for in vivo studies by developing a ratiometric nanoparticle for NO (rNP-NO), which we employed to successfully visualize pathological levels of nitric oxide in a drug-induced liver injury model via deep tissue SWIR photoacoustic (PA) imaging. Our work demonstrates how easily this dye series can be utilized as a component in nanosensor designs for imaging studies.
Identifiants
pubmed: 36722146
doi: 10.1002/anie.202214855
pmc: PMC10088865
mid: NIHMS1871284
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Xanthenes
0
Fluorescent Dyes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202214855Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133581
Pays : United States
Organisme : National Institute of Health
ID : R35GM133581
Informations de copyright
© 2023 Wiley-VCH GmbH.
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