CCR4
Chemokine receptors
Clonal expansion
Psoriasis and psoriatic arthritis
Self-reactive CD8 T cells
T-cell recirculation
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
23
01
2023
received:
27
10
2021
accepted:
30
01
2023
medline:
12
4
2023
pubmed:
2
2
2023
entrez:
1
2
2023
Statut:
ppublish
Résumé
Psoriasis is a chronic inflammatory skin disease with an autoimmune component and associated with joint inflammation in up to 30% of cases. To investigate autoreactive T cells, we developed an imiquimod-induced psoriasis-like inflammation model in K5-mOVA.tg C57BL/6 mice expressing ovalbumin (OVA) on the keratinocyte membrane, adoptively transferred with OT-I OVA-specific CD8
Identifiants
pubmed: 36722608
doi: 10.1002/eji.202149702
doi:
Substances chimiques
Imiquimod
P1QW714R7M
Receptors, Antigen, T-Cell
0
CCR4 protein, human
0
Receptors, CCR4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2149702Subventions
Organisme : The National Psoriasis Foundation-NPF
Organisme : University of Ferrara
ID : 2020-FAR.L-CF_003
Organisme : University of Ferrara
ID : 2021-FAR.L-CF_002
Informations de copyright
© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
Références
Boehncke, W. H. and Schon, M. P., Psoriasis. Lancet 2015. 386: 983-994.
Ceponis, A. and Kavanaugh, A., Use of methotrexate in patients with psoriatic arthritis. Clin. Exp. Rheumatol. 2010. 28: S132-S137.
Chandran, V. and Gladman, D. D., Update on biomarkers in psoriatic arthritis. Curr. Rheumatol. Rep. 2010. 12: 288-294.
Siegel, D., Devaraj, S., Mitra, A., Raychaudhuri, S. P., Raychaudhuri, S. K. and Jialal, I., Inflammation, atherosclerosis, and psoriasis. Clin. Rev. Allergy Immunol. 2013. 44: 194-204.
Ghoreschi, K., Balato, A., Enerback, C. and Sabat, R., Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet 2021. 397: 754-766.
Conrad, C., Domizio, J. D., Mylonas, A., Belkhodja, C., Demaria, O., Navarini, A. A., Lapointe, A. K. et al., TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis. Nat. Commun. 2018. 9: 25.
Mylonas, A. and Conrad, C., Psoriasis: classical vs. paradoxical. The Yin-Yang of TNF and type I interferon. Front. Immunol. 2018. 9: 2746.
Bridgewood, C., Fearnley, G. W., Berekmeri, A., Laws, P., Macleod, T., Ponnambalam, S., Stacey, M. et al., IL-36gamma is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis. Front. Immunol. 2018. 9: 200.
Glitzner, E., Korosec, A., Brunner, P. M., Drobits, B., Amberg, N., Schonthaler, H. B., Kopp, T. et al., Specific roles for dendritic cell subsets during initiation and progression of psoriasis. EMBO Mol. Med. 2014. 6: 1312-1327.
Bose, F., Petti, L., Diani, M., Moscheni, C., Molteni, S., Altomare, A., Rossi, R. L. et al., Inhibition of CCR7/CCL19 axis in lesional skin is a critical event for clinical remission induced by TNF blockade in patients with psoriasis. Am. J. Pathol. 2013. 183: 413-421.
Bergen, L. L. T., Petrovic, A., Aarebrot, A. K. and Appel, S., Current knowledge on autoantigens and autoantibodies in psoriasis. Scand. J. Immunol. 2020. 92: e12945.
Prinz, J. C., Human leukocyte antigen-class I alleles and the autoreactive T cell response in psoriasis pathogenesis. Front. Immunol. 2018. 9: 954.
Vural, S., Kerl, K., Dogan, P. E., Vollmer, S., Puchta, U., He, M., Arakawa, Y. et al., Lesional activation of T(c) 17 cells in Behcet disease and psoriasis supports HLA class I-mediated autoimmune responses. Br. J. Dermatol. 2021. 185: 1209-1220.
Arakawa, A., Siewert, K., Stohr, J., Besgen, P., Kim, S. M., Ruhl, G., Nickel, J. et al., Melanocyte antigen triggers autoimmunity in human psoriasis. J. Exp. Med. 2015. 212: 2203-2212.
Lande, R., Botti, E., Jandus, C., Dojcinovic, D., Fanelli, G., Conrad, C., Chamilos, G. et al., The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis. Nat. Commun. 2014. 5: 5621.
Sgambelluri, F., Diani, M., Altomare, A., Frigerio, E., Drago, L., Granucci, F., Banfi, G. et al., A role for CCR5(+)CD4 T cells in cutaneous psoriasis and for CD103(+) CCR4(+) CD8 Teff cells in the associated systemic inflammation. J. Autoimmun. 2016. 70: 80-90.
Bromley, S. K., Yan, S., Tomura, M., Kanagawa, O. and Luster, A. D., Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. J. Immunol. 2013. 190: 970-976.
Diani, M., Casciano, F., Marongiu, L., Longhi, M., Altomare, A., Pigatto, P. D., Secchiero, P. et al., Increased frequency of activated CD8(+) T cell effectors in patients with psoriatic arthritis. Sci. Rep. 2019. 9: 10870.
Diani, M., Galasso, M., Cozzi, C., Sgambelluri, F., Altomare, A., Cigni, C., Frigerio, E. et al., Blood to skin recirculation of CD4(+) memory T cells associates with cutaneous and systemic manifestations of psoriatic disease. Clin. Immunol. 2017. 180: 84-94.
Penkava, F., Velasco-Herrera, M. D. C., Young, M. D., Yager, N., Nwosu, L. N., Pratt, A. G., Lara, A. L. et al., Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat. Commun. 2020. 11: 4767.
van der Fits, L., Mourits, S., Voerman, J. S., Kant, M., Boon, L., Laman, J. D., Cornelissen, F. et al., Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 2009. 182: 5836-5845.
Azukizawa, H., Kosaka, H., Sano, S., Heath, W. R., Takahashi, I., Gao, X. H., Sumikawa, Y. et al., Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes. Eur. J. Immunol. 2003. 33: 1879-1888.
Ramirez-Valle, F., Gray, E. E. and Cyster, J. G., Inflammation induces dermal Vgamma4+ gammadeltaT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc. Natl. Acad. Sci. U. S. A. 2015. 112: 8046-8051.
Schaper, K., Dickhaut, J., Japtok, L., Kietzmann, M., Mischke, R., Kleuser, B. and Baumer, W., Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. J. Dermatol. Sci. 2013. 71: 29-36.
Cheuk, S., Wiken, M., Blomqvist, L., Nylen, S., Talme, T., Stahle, M. and Eidsmo, L., Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis. J. Immunol. 2014. 192: 3111-3120.
Serezal, I. G., Hoffer, E., Ignatov, B., Martini, E., Zitti, B., Ehrstrom, M. and Eidsmo, L., A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis. J. Allergy Clin. Immunol. 2019. 143: 1444-1454.
Choi, J. W., Gardell, S. E., Herr, D. R., Rivera, R., Lee, C. W., Noguchi, K., Teo, S. T. et al., FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc. Natl. Acad. Sci. U. S. A. 2011. 108: 751-756.
Casciano, F., Diani, M., Altomare, A., Granucci, F., Secchiero, P., Banfi, G. and Reali, E., CCR4(+) skin-tropic phenotype as a feature of central memory CD8(+) T cells in healthy subjects and psoriasis patients. Front. Immunol. 2020. 11: 529.
Nolz, J. C., Molecular mechanisms of CD8(+) T cell trafficking and localization. Cell. Mol. Life Sci. 2015. 72: 2461-2473.
Wirth, T. C., Xue, H. H., Rai, D., Sabel, J. T., Bair, T., Harty, J. T. and Badovinac, V. P., Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation. Immunity 2010. 33: 128-140.
Slutter, B., Pewe, L. L., Kaech, S. M. and Harty, J. T., Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity 2013. 39: 939-948.
Mueller, S. N., Gebhardt, T., Carbone, F. R. and Heath, W. R., Memory T cell subsets, migration patterns, and tissue residence. Annu. Rev. Immunol. 2013. 31: 137-161.
Klicznik, M. M., Morawski, P. A., Hollbacher, B., Varkhande, S. R., Motley, S. J., Kuri-Cervantes, L., Goodwin, E. et al., Human CD4(+)CD103(+) cutaneous resident memory T cells are found in the circulation of healthy individuals. Sci. Immunol. 2019. 4: eaav8995.
Matsuo, K., Kitahata, K., Kaibori, Y., Arima, Y., Iwama, A., Ito, M., Hara, Y. et al., CCR4 involvement in the expansion of T helper type 17 cells in a mouse model of psoriasis. J. Invest. Dermatol. 2021. 141: 1985-1994.
Bos, F., Capsoni, F., Molteni, S., Raeli, L., Diani, M., Altomare, A., Garavaglia, M. et al., Differential expression of interleukin-2 by anti-CD3-stimulated peripheral blood mononuclear cells in patients with psoriatic arthritis and patients with cutaneous psoriasis. Clin. Exp. Dermatol. 2014. 39: 385-390.
Maurice, N. J., McElrath, M. J., Andersen-Nissen, E., Frahm, N. and Prlic, M., CXCR3 enables recruitment and site-specific bystander activation of memory CD8(+) T cells. Nat. Commun. 2019. 10: 4987.
Li, Q., Yan, Y., Liu, J., Huang, X., Zhang, X., Kirschning, C., Xu, H. C. et al., Toll-like receptor 7 activation enhances CD8+ T cell effector functions by promoting cellular glycolysis. Front. Immunol. 2019. 10: 2191.
Fenix, K., Wijesundara, D. K., Cowin, A. J., Grubor-Bauk, B. and Kopecki, Z., Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis. Int. J. Mol. Sci. 2020. 21: 7228.
Curran, S. A., FitzGerald, O. M., Costello, P. J., Selby, J. M., Kane, D. J., Bresnihan, B. and Winchester, R., Nucleotide sequencing of psoriatic arthritis tissue before and during methotrexate administration reveals a complex inflammatory T cell infiltrate with very few clones exhibiting features that suggest they drive the inflammatory process by recognizing autoantigens. J. Immunol. 2004. 172: 1935-1944.
Nelson, D., Bundell, C. and Robinson, B., In vivo cross-presentation of a soluble protein antigen: kinetics, distribution, and generation of effector CTL recognizing dominant and subdominant epitopes. J. Immunol. 2000. 165: 6123-6132.
Vanderlugt, C. L. and Miller, S. D., Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat. Rev. Immunol. 2002. 2: 85-95.
Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., 3rd, Zheng, S., Butler, A., Lee, M. J. et al., Integrated analysis of multimodal single-cell data. Cell 2021. 184: 3573 e3529-3587 e3529.
Hafemeister, C. and Satija, R., Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol. 2019. 20: 296.
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y. et al., Fast, sensitive and accurate integration of single-cell data with Harmony. Nat. Methods 2019. 16: 1289-1296.
Aran, D., Looney, A. P., Liu, L., Wu, E., Fong, V., Hsu, A., Chak, S. et al., Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat. Immunol. 2019. 20: 163-172.
Martens, J. H. and Stunnenberg, H. G., BLUEPRINT: mapping human blood cell epigenomes. Haematologica. 2013. 98: 1487-1489.
Consortium, E. P., An integrated encyclopedia of DNA elements in the human genome. Nature 2012. 489: 57-74.
Borcherding, N., Bormann, N. L. and Kraus, G., scRepertoire: an R-based toolkit for single-cell immune receptor analysis. F1000Res. 2020. 9: 47.