Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
01 03 2023
01 03 2023
Historique:
received:
25
09
2022
accepted:
10
01
2023
pmc-release:
01
03
2024
pubmed:
3
2
2023
medline:
7
3
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity). Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion. Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.
Identifiants
pubmed: 36727859
doi: 10.14309/ajg.0000000000002192
pii: 00000434-202303000-00039
pmc: PMC9992331
mid: NIHMS1866458
doi:
Substances chimiques
Gliadin
9007-90-3
Immunoglobulin A
0
Autoantibodies
0
Immunoglobulin G
0
Biomarkers
0
Transglutaminases
EC 2.3.2.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
574-577Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK122127
Pays : United States
Organisme : NIDDK NIH HHS
ID : L40 DK115176
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104344
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI156711
Pays : United States
Informations de copyright
Copyright © 2023 by The American College of Gastroenterology.
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