Metagenomic Analysis of the Abundance and Composition of Antibiotic Resistance Genes in Hospital Wastewater in Benin, Burkina Faso, and Finland.
West Africa
antibiotic resistance
carbapenemase
colistin resistance
hospital wastewater (HWW)
metagenomes
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
21 02 2023
21 02 2023
Historique:
pubmed:
3
2
2023
medline:
25
2
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
Antibiotic resistance is a global threat to human health, with the most severe effect in low- and middle-income countries. We explored the presence of antibiotic resistance genes (ARGs) in the hospital wastewater (HWW) of nine hospitals in Benin and Burkina Faso, two low-income countries in West Africa, with shotgun metagenomic sequencing. For comparison, we also studied six hospitals in Finland. The highest sum of the relative abundance of ARGs in the 68 HWW samples was detected in Benin and the lowest in Finland. HWW resistomes and mobilomes in Benin and Burkina Faso resembled each other more than those in Finland. Many carbapenemase genes were detected at various abundances, especially in HWW from Burkina Faso and Finland. The
Identifiants
pubmed: 36728456
doi: 10.1128/msphere.00538-22
pmc: PMC9942590
doi:
Substances chimiques
Anti-Bacterial Agents
0
Wastewater
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0053822Références
Antimicrob Agents Chemother. 2010 Aug;54(8):3471-4
pubmed: 20516288
Elife. 2021 May 04;10:
pubmed: 33944776
Bioinformatics. 2015 May 15;31(10):1674-6
pubmed: 25609793
Antimicrob Agents Chemother. 2001 Sep;45(9):2598-603
pubmed: 11502535
BMC Biol. 2019 Jun 12;17(1):48
pubmed: 31189463
Clin Infect Dis. 2005 May 1;40(9):1333-41
pubmed: 15825037
Nat Microbiol. 2021 Jan;6(1):3-6
pubmed: 33349678
Virulence. 2017 May 19;8(4):460-469
pubmed: 27593176
Sci Total Environ. 2019 Dec 1;694:133454
pubmed: 31398645
Sci Total Environ. 2020 Jan 1;698:134201
pubmed: 31505362
Nat Commun. 2021 Aug 6;12(1):4765
pubmed: 34362925
Bioinformatics. 2012 Dec 1;28(23):3150-2
pubmed: 23060610
Bioinformatics. 2015 Oct 15;31(20):3350-2
pubmed: 26099265
Water Res X. 2020 Feb 04;7:100045
pubmed: 32072151
Lancet Infect Dis. 2021 Jan;21(1):29-30
pubmed: 33357390
Ann Clin Microbiol Antimicrob. 2015 Jan 17;14:5
pubmed: 25595314
J Enzyme Inhib Med Chem. 2017 Dec;32(1):917-919
pubmed: 28719998
Microbiome. 2014 May 05;2:15
pubmed: 24910773
Nature. 2017 Nov 23;551(7681):457-463
pubmed: 29088705
Environ Res. 2019 Jan;168:14-24
pubmed: 30253312
Sci Adv. 2019 Mar 27;5(3):eaau9124
pubmed: 30944853
Lancet Infect Dis. 2013 Dec;13(12):1057-98
pubmed: 24252483
PLoS One. 2013 Apr 22;8(4):e61217
pubmed: 23630581
Int J Antimicrob Agents. 2017 Nov;50(5):629-639
pubmed: 28705671
J Glob Antimicrob Resist. 2020 Mar;20:170-177
pubmed: 31401170
J Glob Antimicrob Resist. 2020 Jun;21:8-12
pubmed: 31525542
Clin Microbiol Infect. 2014 Sep;20(9):821-30
pubmed: 24930781
Antimicrob Agents Chemother. 2005 Jan;49(1):202-8
pubmed: 15616297
J Antimicrob Chemother. 2017 Dec 01;72(12):3317-3324
pubmed: 28962028
Front Microbiol. 2017 Nov 15;8:2224
pubmed: 29187837
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
Antimicrob Resist Infect Control. 2021 Mar 31;10(1):63
pubmed: 33789754
Antibiotics (Basel). 2019 Aug 19;8(3):
pubmed: 31430964
Antimicrob Agents Chemother. 2019 Oct 22;63(11):
pubmed: 31481439
Environ Int. 2021 Nov;156:106641
pubmed: 34015664
Nat Commun. 2018 Sep 24;9(1):3891
pubmed: 30250208
Front Med (Lausanne). 2019 Sep 23;6:205
pubmed: 31608280
Germs. 2020 Dec 28;10(4):367-379
pubmed: 33489952
Nat Commun. 2019 Mar 8;10(1):1124
pubmed: 30850636
Gigascience. 2022 Jul 30;11:
pubmed: 35906888
J Antimicrob Chemother. 2020 Dec 1;75(12):3491-3500
pubmed: 32780112
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Diagn Microbiol Infect Dis. 2017 Jul;88(3):282-286
pubmed: 28427794
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Mol Ecol Resour. 2015 Nov;15(6):1403-14
pubmed: 25732605
Antimicrob Agents Chemother. 2014;58(2):936-49
pubmed: 24277043
Int J Antimicrob Agents. 2021 Jan;57(1):106203
pubmed: 33075511
Antimicrob Agents Chemother. 2019 May 24;63(6):
pubmed: 30910897
Lancet Planet Health. 2018 Sep;2(9):e398-e405
pubmed: 30177008
Gigascience. 2019 Sep 1;8(9):
pubmed: 31544212
F1000Res. 2021 Jan 18;10:33
pubmed: 34035898
ISME J. 2015 Jun;9(6):1269-79
pubmed: 25500508
Antimicrob Resist Infect Control. 2021 Jan 14;10(1):13
pubmed: 33446266
P T. 2015 Apr;40(4):277-83
pubmed: 25859123
Biomed Res Int. 2021 Jan 22;2021:6630379
pubmed: 33553426
Nat Rev Microbiol. 2015 Feb;13(2):116-23
pubmed: 25534811
Science. 2019 Sep 20;365(6459):
pubmed: 31604207
Int J Antimicrob Agents. 2020 Sep;56(3):106108
pubmed: 32721596
Biomed Res Int. 2014;2014:303104
pubmed: 24707481
Environ Sci Technol. 2017 May 16;51(10):5721-5728
pubmed: 28426231
Eur J Clin Microbiol Infect Dis. 2020 Sep;39(9):1651-1656
pubmed: 32307627
J Antimicrob Chemother. 2020 Nov 1;75(11):3087-3095
pubmed: 32514524
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
J Antimicrob Chemother. 2015 Jan;70(1):23-40
pubmed: 25261423
Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):321-31
pubmed: 6109327
Clin Microbiol Infect. 2012 Sep;18(9):907-13
pubmed: 22128805
Commun Biol. 2020 Nov 26;3(1):711
pubmed: 33244050
Microbiol Mol Biol Rev. 2014 Jun;78(2):257-77
pubmed: 24847022