Stress biomarkers in individuals with fibromyalgia syndrome: a systematic review with meta-analysis.
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
01 Jul 2023
01 Jul 2023
Historique:
received:
12
07
2022
accepted:
25
11
2022
medline:
19
6
2023
pubmed:
3
2
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
Evidence suggests an involvement of hypothalamic-pituitary-adrenal (HPA) axis dysregulation in the development and maintenance of fibromyalgia syndrome (FMS). However, studies on the stress response via the HPA-axis in individuals with FMS show conflicting results. To better understand the relationship between FMS and HPA-axis dysregulation, we (1) systematically summarized the current level of evidence on HPA biomarkers in individuals with FMS compared with individuals without and (2) evaluated whether FMS is associated with a specific pattern of HPA dysregulation. The main outcome measures were cortisol, adrenocorticotropic hormone (ACTH), corticotropin-releasing hormone (CRH), epinephrine, and norepinephrine. A systematic search of MEDLINE, EMBASE, and PsychMed yielded 47 studies eligible for meta-analysis, including 1465 individuals with FMS and 1192 FMS-free controls. No main effect of FMS was found on altered levels of blood cortisol, ACTH, CRH, and epinephrine. Compared with controls, salivary and urinary cortisol levels were decreased in individuals with FMS, whereas blood levels of norepinephrine were increased. However, heterogeneity of data was high with significant evidence for publication bias. Overall, the data are compatible with association of FMS with adrenocortical hypofunction in the presence of increased sympathetic tone. However, the data are partially contradictory, so it must be assumed that the data are highly dependent on the respective study designs, patient samples, and analytical methods and do not necessarily demonstrate an abnormal HPA-axis function in FMS.
Identifiants
pubmed: 36728497
doi: 10.1097/j.pain.0000000000002857
pii: 00006396-202307000-00003
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Adrenocorticotropic Hormone
9002-60-2
Corticotropin-Releasing Hormone
9015-71-8
Epinephrine
YKH834O4BH
Norepinephrine
X4W3ENH1CV
Biomarkers
0
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1416-1427Informations de copyright
Copyright © 2023 International Association for the Study of Pain.
Références
Adler GK, Kinsley BT, Hurwitz S, Mossey CJ, Goldenberg DL. Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. Am J Med 1999;106:534–43.
Afari N, Ahumada SM, Wright LJ, Mostoufi S, Golnari G, Reis V, Cuneo JG. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosomatic Med 2014;76:2–11.
Al-Nimer MS, Mohammad TA, Maroof AM. Dysfunction of anterior pituitary gland in women patients with recent fibromyalgia: a cross-sectional observational study. Electron J Gen Med 2018;15:em58.
Behrends J, Bischofberger J, Deutzmann R, Ehmke H, Frings S, Grissmer S, Hoth M, Kurtz A, Leipziger J, Müller F. Duale Reihe Physiologie. Thieme, 2021.
Borchers AT, Gershwin ME. Fibromyalgia: a critical and comprehensive review. Clinic Rev Allerg Immunol 2015;49:100–51.
Bote ME, Garcia JJ, Hinchado MD, Ortega E. Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise. PLoS One 2013;8:e74524.
Bote ME, García JJ, Hinchado MD, Ortega E. Inflammatory/stress feedback dysregulation in women with fibromyalgia. Neuroimmunomodulation 2012;19:343–51.
Cakit O, Gümüştepe A, Duyur Çakit B, Pervane Vural S, Özgün T, Genc H. Coexistence of fibromyalgia and metabolic syndrome in females: the effects on fatigue, clinical features, pain sensitivity, urinary cortisol and norepinephrine levels: a cross-sectional study. Arch Rheumatol 2021;36:26–37.
Chai Y, Li Q, Wang Y, Tao E, Asakawa T. The value of HPA axis hormones as biomarkers for screening and early diagnosis of postpartum depression: updated information about methodology. Front Endocrinol 2022;13:916611.
Chervin RD, Teodoresci M, Kushwaha R, Deline AM, Brucksch CB, Ribbens-Grimm C, Ruzicka DL, Stein PK, Clauw DJ, Crofford LJ. Objective measures of disordered sleep fibromyalgia. Joun Rheum 2009;36:2009–16.
Cohen J. Statistical power analysis for the behavioral sciences. New York: Routledge, 1988.
Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL. Hypothalamic–pituitary–adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 1994;37:1583–92.
Crofford LJ, Young EA, Engleberg NC, Korszun A, Brucksch CB, McClure LA, Brown MB, Demitrack MA. Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Brain Behav Immun 2004;18:314–25.
de Abreu Freitas RP, Lemos TMAM, Spyrides MHC, de Sousa MBC. Influence of cortisol and DHEA-S on pain and other symptoms in post menopausal women with fibromyalgia. J Back Musculoskelet Rehabil 2012;25:245–52.
El-Farhan N, Rees DA, Evans C. Measuring cortisol in serum, urine and saliva—are our assays good enough? Ann Clin Biochem 2017;54:308–22.
Fries E, Hesse J, Hellhammer J, Hellhammer DH. A new view on hypocortisolism. Psychoneuroendocrinology 2005;30:1010–6.
Galvez-Sánchez CM, Duschek S, Reyes del Paso GA. Psychological impact of fibromyalgia: current perspectives. Psychol Res Behav Manag 2019;12:117–27.
Geiss A, Rohleder N, Anton F. Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia. Psychoneuroendocrinology 2012;37:671–84.
González-Vives S, Díaz-Marsá M, De la Vega I, Palomares N, Vázquez S, López-Villatoro JM, Palomo T, Carrasco JL. Hypothalamic-pituitary axis response to a 0.25-MG dexamethasone test in women with fibromyalgia. Stress 2020;23:284–9.
Grouzmann E, Lamine F. Determination of catecholamines in plasma and urine. Best Pract Res Clin Endocrinol Metab 2013;27:713–23.
Gur A, Cevik R, Nas K, Colpan L, Sarac S. Cortisol and hypothalamic–pituitary–gonadal axis hormones in follicular-phase women with fibromyalgia and chronic fatigue syndrome and effect of depressive symptoms on these hormones. Arthritis Res Ther 2004;6:R232–8.
Gur A, Cevik R, Sarac A, Colpan L, Em S. Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism. Ann Rheum Dis 2004;63:1504–6.
Gürsel Y, Ergin S, Ulus Y, Erdoğan MF, Yalçın P, Evcik D. Hormonal responses to exercise stress test in patients with fibromyalgia syndrome. Clin Rheumatol 2001;20:401–5.
Hartling L, Hamm M, Milne A, Vandermeer B, Santaguida PL, Ansari M, Tsertsvadze A, Hempel S, Shekelle P, Dryden DM. AHRQ methods for effective health care. Validity and inter-rater reliability testing of quality assessment instruments. Rockville, MD: Agency for Healthcare Research and Quality (US), 2012.
Heim C, Nater UM, Maloney E, Boneva R, Jones JF, Reeves WC. Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction. Arch Gen Psychiatry 2009;66:72–80.
Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, Miller AH, Nemeroff CB. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 2000;284:592–7.
Hellhammer J, Fries E, Schweisthal O, Schlotz W, Stone A, Hagemann D. Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state-and trait components. Psychoneuroendocrinology 2007;32:80–6.
Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. Chichester, United Kingdom: John Wiley & Sons, 2008.
Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA. Cochrane handbook for systematic reviews of interventions. John Wiley & Sons, 2019.
Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta‐analysis. Stat Med 2002;21:1539–58.
Illescas-Montes R, Costela-Ruiz VJ, Melguizo-Rodríguez L, De Luna-Bertos E, Ruiz C, Ramos-Torrecillas J. Application of salivary biomarkers in the diagnosis of fibromyalgia. Diagnostics 2021;11:63.
Izquierdo–Álvarez S, Bocos–Terraz JP, Bancalero–Flores JL, Pavón–Romero L, Serrano–Ostariz E, de Miquel CA. Is there an association between fibromyalgia and below-normal levels of urinary cortisol? BMC Research Notes 2008;1:1–4.
Kadetoff D, Kosek E. Evidence of reduced sympatho-adrenal and hypothalamic-pituitary activity during static muscular work in patients with fibromyalgia. J Rehabil Med 2010;42:765–72.
Kaufmann I, Schelling G, Eisner C, Richter HP, Krauseneck T, Vogeser M, Hauer D, Campolongo P, Chouker A, Beyer A, Thiel M. Anandamide and neutrophil function in patients with fibromyalgia. Psychoneuroendocrinology 2008;33:676–85.
Keeshin BR, Strawn JR, Out D, Granger DA, Putnam FW. Elevated salivary alpha amylase in adolescent sexual abuse survivors with posttraumatic stress disorder symptoms. J Child Adolesc Psychopharmacol 2015;25:344–50.
Kleshchova O, Rieder JK, Grinband J, Weierich MR. Resting amygdala connectivity and basal sympathetic tone as markers of chronic hypervigilance. Psychoneuroendocrinology 2019;102:68–78.
Klingmann PO, Kugler I, Steffke TS, Bellingrath S, Kudielka BM, Hellhammer DH. Sex‐specific prenatal programming: a risk for fibromyalgia? Ann N Y Acad Sci 2008;1148:446–55.
Koca TT, Çimen A. The association of carotid intima-media thickness with body mass index and cortisol level in fibromyalgia syndrome. Eur Res J 2019;5:83–7.
Kozlov AI, Kozlova MA. Cortisol as stress marker. Fiziol Chel 2014;40:123–36.
Kumbhare D, Hassan S, Diep D, Duarte FCK, Hung J, Damodara S, West DW, Selvaganapathy PR. Potential role of blood biomarkers in patients with fibromyalgia: a systematic review with meta-analysis. PAIN 2022;163:1232–53.
Latendresse G, Ruiz RJ. Bioassay research methodology: measuring CRH in pregnancy. Biol Res Nurs 2008;10:54–62.
Lee DY, Kim E, Choi MH. Technical and clinical aspects of cortisol as a biochemical marker of chronic stress. BMB Rep 2015;48:209–16.
Lentjes E, Griep E, Boersma J, Romijn F, de Kloer E. Glucocorticoid receptors, fibromyalgia and low back pain. Psychoneuroendocrinology 1997;22:603–14.
Light KC, Bragdon EE, Grewen KM, Brownley KA, Girdler SS, Maixner W. Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. J Pain 2009;10:542–52.
Lin Y-J, Ko Y-C, Chow L-H, Hsiao F-J, Liu H-Y, Wang P-N, Chen W-T. Salivary cortisol is associated with cognitive changes in patients with fibromyalgia. Scientific Rep 2021;11:1311.
Macedo JA, Hesse J, Turner JD, Meyer J, Hellhammer DH, Muller CP. Glucocorticoid sensitivity in fibromyalgia patients: decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipper. Psychoneuroendocrinology 2008;33:799–809.
McEwen BS. What is the confusion with cortisol? Chronic Stress 2019;3:2470547019833647.
Miller GE, Chen E, Zhou ES. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull 2007;133:25–45.
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Reprint—preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Phys Ther 2009;89:873–80.
Mouraux A, Iannetti GD. The search for pain biomarkers in the human brain. Brain 2018;141:3290–307.
Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron 2002;34:13–25.
Nicholas M, Vlaeyen JW, Rief W, Barke A, Aziz Q, Benoliel R, Cohen M, Evers S, Giamberardino MA, Goebel A, Korwisi B, Perrot S, Svensson P, Wang SJ, Treede RD; The IASP Taskforce for the Classification of Chronic Pain. The IASP classification of chronic pain for ICD-11: chronic primary pain. PAIN 2019;160:28–37.
Nieman L, Lacroix A, Martin KA. Measurement of ACTH, CRH, and other hypothalamic and pituitary peptides, 2019. Available at: https://www.uptodate.com/contents/measurement-of-acth-crh-and-other-hypothalamic-and-pituitary-peptides
Nieman LK. Measurement of cortisol in serum and saliva, 2006. Available at: https://www.uptodate.com/contents/measurement-of-acth-crh-and-other-hypothalamic-and-pituitary-peptides
Nilsen KB, Sand T, Westgaard RH, Stovner LJ, White LR, Leistad RB, Helde G, Rø M. Autonomic activation and pain in response to low-grade mental stress in fibromyalgia and shoulder/neck pain patients. Eur J Pain 2007;11:743–55.
Noushad S, Ahmed S, Ansari B, Mustafa U-H, Saleem Y, Hazrat H. Physiological biomarkers of chronic stress: a systematic review. Int J Health Sci 2021;15:46–59.
Ortega E, García JJ, Bote ME, Martín-Cordero L, Escalante Y, Saavedra JM, Northoff H, Giraldo E. Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances. Exerc Immunol Rev 2009;15:42–65.
Paiva ES, Deodhar A, Jones KD, Bennett R. Impaired growth hormone secretion in fibromyalgia patients: evidence for augmented hypothalamic somatostatin tone. Arthritis Rheum 2002;46:1344–50.
Pape H, Kurtz A, Silbernagl S. Physiologie. 8., unveränderte Auflage. Stuttgart, New York: Thieme Georg Verlag, 2018.
Plenis A, Olędzka I, Kowalski P, Miękus N, Bączek T. Recent trends in the quantification of biogenic amines in biofluids as biomarkers of various disorders: a review. J Clin Med 2019;8:640.
Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry 2003;160:1554–65.
Riedel W, Layka H, Neeck G. Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Z Rheumatol 1998;57:S81–7.
Riva R, Mork PJ, Westgaard RH, Okkenhaug Johansen T, Lundberg U. Catecholamines and heart rate in female fibromyalgia patients. J Psychosomatic Res 2012;72:51–7.
Riva R, Mork PJ, Westgaard RH, Lundberg U. Comparison of the cortisol awakening response in women with shoulder and neck pain and women with fibromyalgia. Psychoneuroendocrinology 2012;37:299–306.
Riva R, Mork PJ, Westgaard RH, Rø M, Lundberg U. Fibromyalgia syndrome is associated with hypocortisolism. Int J Behav Med 2010;17:223–33.
RStudio Team. RStudio: integrated development environment for R. RStudio. PBC, 2022.
Rus A, Molina F, Del Moral ML, Ramírez-Expósito MJ, Martínez-Martos JM. Catecholamine and indolamine pathway: a case–control study in fibromyalgia. Biol Res Nurs 2018;20:577–86.
Schweinhardt P, Sauro KM, Bushnell MC. Fibromyalgia: a disorder of the brain? Neuroscientist 2008;14:415–21.
Semiz EA, Hizmetli S, Semiz M, Karadağ A, Adalı M, Tuncay MS, Alim B, Hayta E, Uslu AU. Serum cortisol and dehydroepiandrosterone-sulfate levels after balneotherapy and physical therapy in patients with fibromyalgia. Saudi Med J 2016;37:544–50.
Sharpley CF. Neurobiological pathways between chronic stress and depression: dysregulated adaptive mechanisms? Clin Med Insights Psyc 2009;2:CMPsy. S3658.
Sluka KA, Clauw DJ. Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience 2016;338:114–29.
Southwick SM, Bremner JD, Rasmusson A, Morgan CA III, Arnsten A, Charney DS. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry 1999;46:1192–204.
Sterne JA, Egger M. Regression methods to detect publication and other bias in meta-analysis. Chichester, United Kingdom: John Wiley & Sons, Vol. 99, 2005.
Tak LM, Cleare AJ, Ormel J, Manoharan A, Kok IC, Wessely S, Rosmalen JG. Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders. Biol Psychol 2011;87:183–94.
Talbot J, Kane J, White A. Analytical and clinical aspects of adrenocorticotrophin determination. Ann Clin Biochem 2003;40:453–71.
Tanriverdi F, Karaca Z, Unluhizarci K, Kelestimur F. The hypothalamo–pituitary–adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome. Stress 2007;10:13–25.
Tesarz J, Eich W, Baumeister D, Kohlmann T, D'Agostino R, Schuster AK. Widespread pain is a risk factor for cardiovascular mortality: results from the Framingham Heart Study. Eur Heart J 2019;40:1609–17.
Tesarz J, Eich W, Treede R-D, Gerhardt A. Altered pressure pain thresholds and increased wind-up in adult patients with chronic back pain with a history of childhood maltreatment: a quantitative sensory testing study. PAIN 2016;157:1799–809.
Tesarz J, Gerhardt A, Eich W. Influence of early childhood stress exposure and traumatic life events on pain perception. Schmerz 2018;32:243–9.
Thomas L. Labor und Diagnose: Indikation und Bewertung von Laborbefunden für die medizinische Diagnostik. TH-Books-Verlag-Ges, 2008.
Torgrimson-Ojerio B, Ross RL, Dieckmann NF, Avery S, Bennett RM, Jones KD, Guarino AJ, Wood LJ. Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia. J Neuroimmunol 2014;277:160–7.
Torpy DJ, Papanicolaou DA, Lotsikas AJ, Wilder RL, Chrousos GP, Pillemer SR. Responses of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis to interleukin‐6: a pilot study in fibromyalgia. Arthritis Rheum 2000;43:872–80.
Úbeda-D’Ocasar E, Jiménez Díaz-Benito V, Gallego-Sendarrubias GM, Valera-Calero JA, Vicario-Merino Á, Hervás-Pérez JP. Pain and cortisol in patients with fibromyalgia: systematic review and meta-analysis. Diagnostics 2020;10:922.
Van Denderen JC, Boersma JW, Zeinstra P, Hollander AP, Van Neerbos BR. Physiological effects of exhaustive physical exercise in primary fibromyalgia syndrome (PFS): is PFS a disorder of neuroendocrine reactivity? Scand J Rheumatol 1992;21:35–7.
Van Houdenhove B, Egle U, Luyten P. The role of life stress in fibromyalgia. Curr Rheumatol Rep 2005;7:365–70.
Van Houdenhove B, Egle UT. Fibromyalgia: a stress disorder? Psychother Psychosom 2004;73:267–75.
Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw 2010;36:1–48.
Wingenfeld K, Nutzinger D, Kauth J, Hellhammer DH, Lautenbacher S. Salivary cortisol release and hypothalamic pituitary adrenal axis feedback sensitivity in fibromyalgia is associated with depression but not with pain. J Pain 2010;11:1195–202.
Wingenfeld K, Wagner D, Schmidt I, Meinlschmidt G, Hellhammer DH, Heim C. The low-dose dexamethasone suppression test in fibromyalgia. J Psychosom Res 2007;62:85–91.