Mitochondria in Cryptococcus: an update of mitochondrial transcriptional regulation in Cryptococcus.
Cryptococcus neoformans
Heat shock factor
Mitochondria
Virulence
Journal
Current genetics
ISSN: 1432-0983
Titre abrégé: Curr Genet
Pays: United States
ID NLM: 8004904
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
27
12
2022
accepted:
19
01
2023
revised:
19
01
2023
pubmed:
3
2
2023
medline:
16
2
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
Encapsulated Cryptococcus species are responsible for approximately 15% of AIDS-related mortality. Numerous intriguing investigations have demonstrated that mitochondria play a crucial role in the pathogen-host axis of microorganisms. Mitochondria are vital energy-generating organelles, but they also regulate a variety of cellular activities, such as fungal adaptability in the host and drug resistance. Mitochondria are also the source of reactive oxygen species, which serve as intracellular messengers but are harmful when produced in excess. Thus, precise and stringent regulation of mitochondrial activity, including oxidative phosphorylation and the ROS detoxification process, is essential to ensure that only the amount required to maintain basic biological activities and prevent ROS toxicity in the cell is maintained. However, the relationship between mitochondria and the pathogenicity of Cryptococcus remains poorly understood. In this review, we focus on transcription regulation and maintenance of mitochondrial function along the pathogen-host interaction axis, as well as prospective antifungal strategies that target mitochondria.
Identifiants
pubmed: 36729179
doi: 10.1007/s00294-023-01261-7
pii: 10.1007/s00294-023-01261-7
doi:
Substances chimiques
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-6Subventions
Organisme : National Natural Science Foundation of China
ID : 31870140
Organisme : National Key Research and Development Program of China
ID : 2022YFC2303000
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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