A multi-epitope vaccine GILE against
Echinococcus multilocularis
bioinformatics
immune
multi-epitope vaccine
prokaryotic expression
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
11
2022
accepted:
28
12
2022
entrez:
3
2
2023
pubmed:
4
2
2023
medline:
7
2
2023
Statut:
epublish
Résumé
The objective of this study is to construct a multi-epitope vaccine GILE containing B-cell and T-cell epitopes against The structure and hydrophobicity of GILE were predicted by SWISSMODEL, pyMOL, SOPMA and VMD, and its sequence was optimized by Optimum™ Codon. The GILE gene was inserted into pCzn1 and transformed into The SWISS-MODEL analysis showed that the optimal model was EMY162 A multi-epitope vaccine GILE with good immunogenicity and antigenicity has been successfully constructed in this study, which may provide important theoretical and experimental bases for the prevention and treatment of
Identifiants
pubmed: 36733393
doi: 10.3389/fimmu.2022.1091004
pmc: PMC9887108
doi:
Substances chimiques
Interleukin-4
207137-56-2
Vaccines
0
Recombinant Proteins
0
Interferon-gamma
82115-62-6
Epitopes, T-Lymphocyte
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1091004Informations de copyright
Copyright © 2023 Zhou, Zhou, Huayu, Wang, Feng, Xiao, Dai, Xin, Tang and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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