GLP-1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading.
BOLD
GLP‐1
RBF
arterial spin labelling
kidney
magnetic resonance imaging
perfusion
renal
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
07 02 2023
07 02 2023
Historique:
pubmed:
4
2
2023
medline:
9
2
2023
entrez:
3
2
2023
Statut:
ppublish
Résumé
Background GLP-1 (glucagon-like peptide-1) receptor agonists exert beneficial long-term effects on cardiovascular and renal outcomes. In humans, the natriuretic effect of GLP-1 depends on GLP-1 receptor interaction, is accompanied by suppression of angiotensin II, and is independent of changes in renal plasma flow. In rodents, angiotensin II constricts vasa recta and lowers medullary perfusion. The current randomized, controlled, crossover study was designed to test the hypothesis that GLP-1 increases renal medullary perfusion in healthy humans. Methods and Results Healthy male participants (n=10, aged 27±4 years) ingested a fixed sodium intake for 4 days and were examined twice during a 1-hour infusion of either GLP-1 (1.5 pmol/kg per minute) or placebo together with infusion of 0.9% NaCl (750 mL/h). Interleaved measurements of renal arterial blood flow, oxygenation (R
Identifiants
pubmed: 36734354
doi: 10.1161/JAHA.122.027712
pmc: PMC9973647
doi:
Substances chimiques
Angiotensin II
11128-99-7
Glucagon-Like Peptide 1
89750-14-1
Sodium Chloride
451W47IQ8X
Banques de données
ClinicalTrials.gov
['NCT04337268']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e027712Subventions
Organisme : Medical Research Council
ID : MR/R02264X/1
Pays : United Kingdom
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