Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.

Humans CD8-Positive T-Lymphocytes Interferon-gamma Lung Neoplasms T-Lymphocytes, Cytotoxic T-Lymphocytes, Regulatory
T cell dysfunction T cell priming Th1-like effector regulatory T cells anti-tumor immunity cross-presenting dendritic cells cytotoxic T cells interferon-gamma non-small cell lung cancer regulatory T cells tissue-specific immunity

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
14 02 2023
Historique:
received: 26 05 2022
revised: 27 12 2022
accepted: 11 01 2023
pubmed: 4 2 2023
medline: 18 2 2023
entrez: 3 2 2023
Statut: ppublish

Résumé

Local environmental factors influence CD8

Identifiants

DOI: 10.1016/j.immuni.2023.01.010 PMID: 36736322
pubmed: 36736322
pii: S1074-7613(23)00020-1
doi: 10.1016/j.immuni.2023.01.010
pii:
doi:

Substances chimiques

Interferon-gamma 82115-62-6
IFNG protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

386-405.e10

Subventions

Organisme : NCI NIH HHS
ID : R37 CA273819
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests S.S. is a SAB member for Related Sciences, Arcus Biosciences, Ankyra Therapeutics, and Venn Therapeutics. S.S. is a co-founder of Danger Bio. S.S. is a consultant for TAKEDA, Merck, Tango Therapeutics, and Ribon Therapeutics and receives funding for unrelated projects from Leap Therapeutics. J.C.L. has interests in Sunflower Therapeutics PBC, Pfizer, Honeycomb Biotechnologies, OneCyte Biotechnologies, SQZ Biotechnologies, Alloy Therapeutics, QuantumCyte, Amgen, and Repligen. S.S. and J.C.L.’s interests are reviewed and managed under MIT’s policies for potential conflicts of interest. J.C.L. receives sponsored research support at MIT from Amgen, the Bill & Melinda Gates Foundation, Biogen, Pfizer, Roche, Takeda, and Sanofi.

Auteurs

Maria Zagorulya (M)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA.

Leon Yim (L)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

Duncan M Morgan (DM)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.

Austin Edwards (A)

Biological Imaging Development CoLab, UCSF, San Francisco, CA 94143, USA.

Elen Torres-Mejia (E)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

Noor Momin (N)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

Chloe V McCreery (CV)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

Izabella L Zamora (IL)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

Brendan L Horton (BL)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

James G Fox (JG)

Department of Biological Engineering, MIT, Cambridge, MA 02139, USA; Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA.

K Dane Wittrup (KD)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

J Christopher Love (JC)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Stefani Spranger (S)

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: spranger@mit.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tissue-specific abundance of interferon-gamma...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Tissue-specific abundance of interferon-gamma...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Tissue-specific abundance of interferon-gamma...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tissue-specific abundance of interferon-gamma...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T cytotoxiques › Tissue-specific abundance of interferon-gamma...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Tissue-specific abundance of interferon-gamma...