A narrative review of the principal glucocorticoids employed in cancer.
Glucocorticoids
Immune checkpoint inhibitors
Oncology
Palliative care
Supportive care
Journal
Seminars in oncology
ISSN: 1532-8708
Titre abrégé: Semin Oncol
Pays: United States
ID NLM: 0420432
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
12
09
2022
revised:
15
01
2023
accepted:
16
01
2023
pubmed:
4
2
2023
medline:
15
3
2023
entrez:
3
2
2023
Statut:
ppublish
Résumé
Glucocorticoids (GCs) are a pharmacological class of drugs widely used in oncology in both supportive and palliative settings. GCs differentially impact organs with immediate and long-term effects; with suppressive effect on the immune system anchoring their use to manage the toxicities of immune checkpoint inhibitors (ICIs). In addition, GCs are often used in the management of symptoms related to cancer or chemotherapy and as adjuvants in the treatment of pain in the management of other. In the palliative setting, GCs, especially administered subcutaneously can be to assist in the control of nausea, dyspnea, asthenia, and anorexia-cachexia syndrome. In this narrative review, we aim to summarize the role of GCs in the different settings (curative, supportive, and palliative) to help clinicians use these important drugs in their daily clinical practice with cancer patients.
Identifiants
pubmed: 36737303
pii: S0093-7754(23)00004-0
doi: 10.1053/j.seminoncol.2023.01.004
pii:
doi:
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
429-438Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest B.P. was supported by ESMO with a Clinical Translational Fellowship aid supported by Roche. M.S. acted as consultant for MSD, BMS, Astra-Zeneca, Mercks, Amgen and Servier and received speaker honoraria from MSD, Mercks, Amgen ans Servier. A.M. received research grants from Roche and honoraria from Lilly, Novartis, EISAI, Seagen, Daiichi-Sankyo.