Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.
Alzheimer's disease
age at onset
genetic association
polygenic risk score
quantitative trait
survival model
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
06
12
2022
received:
24
06
2022
accepted:
19
12
2022
medline:
27
7
2023
pubmed:
5
2
2023
entrez:
4
2
2023
Statut:
ppublish
Résumé
Our understanding of the genetic predisposition for age-at-onset (AAO) of Alzheimer's disease (AD) is limited. Here, we sought to identify genes modifying AAO and examined whether any have sex-specific effects. Genome-wide association analysis were performed on imputed genetic data of 9219 AD cases and 10,345 controls from 20 cohorts of the Alzheimer's Disease Genetics Consortium. AAO was modeled from cases directly and as a survival outcome. We identified 11 genome-wide significant loci (P < 5 × 10 Genes that influence AAO of AD are excellent therapeutic targets for delaying onset of AD. Several loci identified include genes with promising functional implications for AD.
Substances chimiques
LUZP2 protein, human
0
DNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3148-3157Subventions
Organisme : NIA NIH HHS
ID : R01 AG062634
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG060472
Pays : United States
Informations de copyright
© 2023 the Alzheimer's Association.
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