Estimated glomerular filtration rate, haemodynamics, and mortality in patients with aortic stenosis.
aortic stenosis
estimated glomerular filtration rate
haemodynamics
pulmonary artery pressure
right atrial pressure
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
02
02
2023
received:
27
12
2022
accepted:
02
02
2023
medline:
16
5
2023
pubmed:
7
2
2023
entrez:
6
2
2023
Statut:
ppublish
Résumé
In aortic stenosis (AS), estimated glomerular filtration rate (eGFR) is an important prognostic marker but its haemodynamic determinants are unknown. We investigated the correlation between eGFR and invasive haemodynamics and long-term mortality in AS patients undergoing aortic valve replacement (AVR). We studied 503 patients [median (interquartile range) age 76 (69-81) years] with AS [indexed aortic valve area .42 (.33-.49) cm The median eGFR was 67 (53-82) mL/min/1.73 m In patients with AS, low eGFR is a marker of an unfavourable haemodynamic constellation as well as important co-morbidities. This may in part explain the association between low eGFR and increased post-AVR mortality.
Sections du résumé
BACKGROUND
BACKGROUND
In aortic stenosis (AS), estimated glomerular filtration rate (eGFR) is an important prognostic marker but its haemodynamic determinants are unknown. We investigated the correlation between eGFR and invasive haemodynamics and long-term mortality in AS patients undergoing aortic valve replacement (AVR).
METHODS
METHODS
We studied 503 patients [median (interquartile range) age 76 (69-81) years] with AS [indexed aortic valve area .42 (.33-.49) cm
RESULTS
RESULTS
The median eGFR was 67 (53-82) mL/min/1.73 m
CONCLUSION
CONCLUSIONS
In patients with AS, low eGFR is a marker of an unfavourable haemodynamic constellation as well as important co-morbidities. This may in part explain the association between low eGFR and increased post-AVR mortality.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13965Informations de copyright
© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.
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