[Oxytocin and its receptor: molecular and therapeutic approaches].
Approches moléculaires et thérapeutiques des interactions entre l’ocytocine et son récepteur.
agoniste
autism
autisme
candidat médicament
drug candidate
interactions moléculaires
molecular interactions
ocytocine et son récepteur
oxytocin agonist
oxytocin and its receptor
Journal
Biologie aujourd'hui
ISSN: 2105-0686
Titre abrégé: Biol Aujourdhui
Pays: France
ID NLM: 101544020
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
06
2022
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
9
2
2023
Statut:
ppublish
Résumé
It is known since the fifties that oxytocin is a neurohormone synthesized in the brain and released in blood circulation to trigger uterus contraction during delivery. It is also involved in milk ejection during breast-feeding. Over the past 25 years, many other central and peripheral functions have been discovered, in particular for attachment between child and parents as well as between individuals and interaction between a human being and its social group. Over this period, we have studied the functional supramolecular architecture of the hormone bound to its receptor. This information was used to design pharmacological probes and drug candidates. This led to the discovery of the first non-peptide oxytocin receptor full agonist. This molecule, LIT-001, restores social interaction in an animal model of autism and paves the way for a treatment of this neurodevelopmental disorder. Approches moléculaires et thérapeutiques des interactions entre l’ocytocine et son récepteur. L’ocytocine est une neurohormone connue à l’origine pour son rôle dans les contractions de l’utérus au moment de l’accouchement et les contractions des glandes mammaires pour permettre l’éjection du lait lors de la tétée. Depuis les 25 dernières années, de multiples autres effets centraux et périphériques ont été identifiés, notamment dans les processus d’attachement entre parents et enfant, entre adultes et entre un individu et son groupe social. Nous avons abordé au cours de cette période la question fondamentale de l’architecture structurale et fonctionnelle du complexe formé par l’ocytocine et son récepteur et l’application de ce savoir à la conception de candidats médicaments. Ceci a conduit à la découverte du premier agoniste non peptidique de l’ocytocine, le LIT-001, restaurant l’interaction sociale dans un modèle animal d’autisme.
Autres résumés
Type: Publisher
(fre)
Approches moléculaires et thérapeutiques des interactions entre l’ocytocine et son récepteur.
Identifiants
pubmed: 36744978
doi: 10.1051/jbio/2022013
pii: jbio220013
doi:
Substances chimiques
Oxytocin
50-56-6
Receptors, Oxytocin
0
Types de publication
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
125-130Informations de copyright
© Société de Biologie, 2023.
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