[Emergent role of astrocytes in oxytocin-mediated modulatory control of neuronal circuits and brain functions].
Rôle émergent des astrocytes dans le contrôle des circuits neuronaux et des fonctions cérébrales modulés par l’ocytocine.
amygdala
amygdale
astrocytes
hypothalamus
ocytocine
oxytocin
Journal
Biologie aujourd'hui
ISSN: 2105-0686
Titre abrégé: Biol Aujourdhui
Pays: France
ID NLM: 101544020
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
09
2022
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
9
2
2023
Statut:
ppublish
Résumé
The neuropeptide oxytocin has been in the focus of scientists for decades due to its profound and pleiotropic effects on physiology, activity of neuronal circuits and behaviors. Until recently, it was believed that oxytocinergic action exclusively occurs through direct activation of neuronal oxytocin receptors. However, several studies demonstrated the existence and functional relevance of astroglial oxytocin receptors in various brain regions in the mouse and rat brain. Astrocytic signaling and activity are critical for many important physiological processes including metabolism, neurotransmitter clearance from the synaptic cleft and integrated brain functions. While it can be speculated that oxytocinergic action on astrocytes predominantly facilitates neuromodulation via the release of gliotransmitters, the precise role of astrocytic oxytocin receptors remains elusive. In this review, we discuss the latest studies on the interaction between the oxytocinergic system and astrocytes, and give details of underlying intracellular cascades. Rôle émergent des astrocytes dans le contrôle des circuits neuronaux et des fonctions cérébrales modulés par l’ocytocine. L’ocytocine est un neuropeptide au centre de l’attention des scientifiques depuis des décennies, en raison de ses effets puissants et pléiotropes tant sur le plan physiologique que sur l’activité des circuits neuronaux, modulant ainsi nos comportements. Jusqu’à une date récente, on pensait que l’action de l’ocytocine était induite exclusivement par l’activation directe de ses récepteurs neuronaux. Cependant, plusieurs études ont démontré l’existence et la pertinence fonctionnelle des récepteurs astrogliaux de l’ocytocine dans diverses régions du cerveau de la souris et du rat. La signalisation et l’activité astrocytaires sont essentielles à de nombreux processus physiologiques importants, notamment le métabolisme, l’élimination des neurotransmetteurs de la fente synaptique et les fonctions cérébrales intégrées. Bien que l’on puisse supposer que l’action de l’ocytocine sur les astrocytes facilite principalement la neuromodulation via la libération de gliotransmetteurs, le rôle précis des récepteurs astrocytaires de l’ocytocine reste difficile à cerner. Dans cette revue, nous discutons des dernières études sur l’interaction entre le système ocytocinergique et les astrocytes, et décrivons les cascades intracellulaires mises en jeu.
Autres résumés
Type: Publisher
(fre)
Rôle émergent des astrocytes dans le contrôle des circuits neuronaux et des fonctions cérébrales modulés par l’ocytocine.
Identifiants
pubmed: 36744981
doi: 10.1051/jbio/2022022
pii: jbio220022
doi:
Substances chimiques
Oxytocin
50-56-6
Receptors, Oxytocin
0
Types de publication
Review
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
155-165Informations de copyright
© Société de Biologie, 2023.
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