Research progress in Th17 cells and the relevant cytokines in Graves
Th17细胞及其相关因子在Graves眼病中的研究进展.
Graves’ ophthalmopathy
Th17 cells
cytokines
Journal
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
ISSN: 1672-7347
Titre abrégé: Zhong Nan Da Xue Xue Bao Yi Xue Ban
Pays: China
ID NLM: 101230586
Informations de publication
Date de publication:
28 Dec 2022
28 Dec 2022
Historique:
entrez:
7
2
2023
pubmed:
8
2
2023
medline:
9
2
2023
Statut:
ppublish
Résumé
Graves' ophthalmopathy is the most common clinical orbital disease, and T helper (Th) cells play an important role in the development of Graves' ophthalmopathy. Th17 cells are a major subpopulation of Th cells and abnormally highly expressed in patients with Graves' ophthalmopathy. Th17 cells and the related cytokines interleukin (IL)-17A, IL-21 and IL-23 are involved in regulating the inflammatory response, fibrosis and adipogenesis. Th17 cells are unstable and exhibit a degree of plasticity, and they can differentiate into IL-17A and interferon (IFN)-γ dual-producing Th17.1 cells, which exacerbate the pathogenicity of Th17 cells. In addition, Th17 cells and the relevant factors are strongly associated with disease activity and severity in Graves' ophthalmopathy. Graves眼病是临床上最常见的眼眶疾病，辅助型T(T helper，Th)细胞在Graves眼病的发展中起重要作用。Th17细胞作为Th细胞的主要亚群在Graves眼病患者中呈高度异常的表达，Th17细胞及相关因子白细胞介素(interleukin，IL)-17A、IL-21和IL-23共同参与炎症反应的调控、纤维化和脂肪的生成。Th17细胞不稳定，可表现出一定程度的可塑性，并可同时分泌IL-17A和干扰素-γ，这会加剧Th17细胞的致病性。此外，Th17细胞及相关炎症因子与Graves眼病的疾病活动度和严重程度密切相关。.
Autres résumés
Type: Publisher
(chi)
Graves眼病是临床上最常见的眼眶疾病，辅助型T(T helper，Th)细胞在Graves眼病的发展中起重要作用。Th17细胞作为Th细胞的主要亚群在Graves眼病患者中呈高度异常的表达，Th17细胞及相关因子白细胞介素(interleukin，IL)-17A、IL-21和IL-23共同参与炎症反应的调控、纤维化和脂肪的生成。Th17细胞不稳定，可表现出一定程度的可塑性，并可同时分泌IL-17A和干扰素-γ，这会加剧Th17细胞的致病性。此外，Th17细胞及相关炎症因子与Graves眼病的疾病活动度和严重程度密切相关。.
Identifiants
pubmed: 36748387
pii: 1672-7347(2022)12-1748-06
doi: 10.11817/j.issn.1672-7347.2022.220205
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
chi
Sous-ensembles de citation
IM
Pagination
1748-1753Subventions
Organisme : Henan Traditional Chinese Medicine Inheritance and Innovation Talent Project (Zhongjing Project) Top-Notch Talents of Traditional Chinese Medicine
ID : CZ0237-02
Organisme : the Special Project of Scientific Research on Traditional Chinese Medicine in Henan Province
ID : 20-21ZY1016
Références
J Autoimmun. 2019 May;99:1-14
pubmed: 30773373
Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2604-2614
pubmed: 29847667
Nat Immunol. 2011 Mar;12(3):255-63
pubmed: 21278737
Autoimmun Rev. 2019 Jul;18(7):673-678
pubmed: 31059842
Endocrinology. 2006 Jan;147(1):13-9
pubmed: 16210363
J Endocrinol Invest. 2021 Nov;44(11):2475-2484
pubmed: 33866536
Endocrinology. 2017 Oct 1;158(10):3676-3683
pubmed: 28938449
Front Immunol. 2019 Aug 07;10:1865
pubmed: 31440249
J Immunol. 2010 Jul 1;185(1):679-87
pubmed: 20511558
J Autoimmun. 2018 Feb;87:1-15
pubmed: 29275836
Clin Endocrinol (Oxf). 2020 Oct;93(4):363-374
pubmed: 32691849
Eye (Lond). 2021 Aug;35(8):2294-2301
pubmed: 33139874
Curr Mol Med. 2018;18(2):83-90
pubmed: 29974826
J Endocrinol Invest. 2020 Feb;43(2):123-137
pubmed: 31538314
J Immunol. 2017 Mar 15;198(6):2249-2259
pubmed: 28167631
Exp Eye Res. 2020 Dec;201:108276
pubmed: 32991886
J Cell Biochem. 2019 Apr;120(4):6299-6303
pubmed: 30565709
J Neuroimmunol. 2007 Feb;183(1-2):96-103
pubmed: 17240458
J Clin Endocrinol Metab. 2017 Nov 1;102(11):4273-4283
pubmed: 28938397
Exp Mol Med. 2021 May;53(5):993-1004
pubmed: 34050263
Thyroid. 2022 Aug;32(8):949-961
pubmed: 35469435
J Clin Med. 2020 Aug 31;9(9):
pubmed: 32878150
J Clin Endocrinol Metab. 2019 May 1;104(5):1697-1711
pubmed: 30517642
J Endocrinol Invest. 2018 Jun;41(6):719-727
pubmed: 29190000
Eur J Endocrinol. 2021 Aug 27;185(4):G43-G67
pubmed: 34297684
Cell Immunol. 2020 Oct;356:104176
pubmed: 32736174
J Clin Endocrinol Metab. 2020 Jun 1;105(6):
pubmed: 32173759
Genet Mol Res. 2011 Oct 31;10(4):3338-46
pubmed: 22057994
Br J Ophthalmol. 2016 Jan;100(1):142-50
pubmed: 26567024
Int Immunopharmacol. 2021 Feb;91:107300
pubmed: 33383445
Eye (Lond). 2019 Feb;33(2):176-182
pubmed: 30531993
Immunity. 2021 Feb 9;54(2):308-323.e6
pubmed: 33421362
Int J Mol Med. 2006 May;17(5):911-6
pubmed: 16596280
J Immunol. 2015 Jul 15;195(2):528-40
pubmed: 26062995
Nature. 2010 Oct 21;467(7318):967-71
pubmed: 20962846
Nat Immunol. 2005 Nov;6(11):1123-32
pubmed: 16200070