Right Ventricular Architectural Remodeling and Functional Adaptation in Pulmonary Hypertension.
physiological adaptation
pulmonary hypertension
right ventricle
strain
ventricle remodeling
Journal
Circulation. Heart failure
ISSN: 1941-3297
Titre abrégé: Circ Heart Fail
Pays: United States
ID NLM: 101479941
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
pmc-release:
07
02
2024
pubmed:
8
2
2023
medline:
25
2
2023
entrez:
7
2
2023
Statut:
ppublish
Résumé
Global indices of right ventricle (RV) function provide limited insights into mechanisms underlying RV remodeling in pulmonary hypertension (PH). While RV myocardial architectural remodeling has been observed in PH, its effect on RV adaptation is poorly understood. Hemodynamic assessments were performed in 2 rodent models of PH. RV free wall myoarchitecture was quantified using generalized Q-space imaging and tractography analyses. Computational models were developed to predict RV wall strains. Data from animal studies were analyzed to determine the correlations between hemodynamic measurements, RV strains, and structural measures. In contrast to the PH rats with severe RV maladaptation, PH rats with mild RV maladaptation showed a decrease in helical range of fiber orientation in the RV free wall (139º versus 97º; Data analysis suggests that adaptive RV architectural remodeling could improve RV function in PH. Our findings suggest the need to assess RV architecture within routine screenings of PH patients to improve our understanding of its prognostic and therapeutic significance in PH.
Sections du résumé
BACKGROUND
Global indices of right ventricle (RV) function provide limited insights into mechanisms underlying RV remodeling in pulmonary hypertension (PH). While RV myocardial architectural remodeling has been observed in PH, its effect on RV adaptation is poorly understood.
METHODS
Hemodynamic assessments were performed in 2 rodent models of PH. RV free wall myoarchitecture was quantified using generalized Q-space imaging and tractography analyses. Computational models were developed to predict RV wall strains. Data from animal studies were analyzed to determine the correlations between hemodynamic measurements, RV strains, and structural measures.
RESULTS
In contrast to the PH rats with severe RV maladaptation, PH rats with mild RV maladaptation showed a decrease in helical range of fiber orientation in the RV free wall (139º versus 97º;
CONCLUSIONS
Data analysis suggests that adaptive RV architectural remodeling could improve RV function in PH. Our findings suggest the need to assess RV architecture within routine screenings of PH patients to improve our understanding of its prognostic and therapeutic significance in PH.
Identifiants
pubmed: 36748476
doi: 10.1161/CIRCHEARTFAILURE.122.009768
pmc: PMC9974595
mid: NIHMS1838596
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e009768Subventions
Organisme : CSRD VA
ID : I01 CX001892
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148727
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128661
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103652
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115677
Pays : United States
Commentaires et corrections
Type : CommentIn
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