Suppression of innate immunity by the vaccinia virus protein N1 promotes skin microbiota expansion and increased immune infiltration following vaccination.

Humans Immunity, Innate Immunologic Factors / metabolism Vaccination Vaccinia Vaccinia virus / genetics Viral Proteins / genetics Skin / microbiology Microbiota
N1 NF-κB Vaccinia virus innate immunity skin microbiota

Journal

The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340

Informations de publication

Date de publication:
11 2022
Historique:
entrez: 7 2 2023
pubmed: 8 2 2023
medline: 9 2 2023
Statut: ppublish

Résumé

Vaccinia virus (VACV) protein N1 is an intracellular immunomodulator that contributes to virus virulence via inhibition of NF-κB. Intradermal infection with a VACV lacking gene

Identifiants

DOI: 10.1099/jgv.0.001814 PMID: 36748513 PMC: PMC7614846
pubmed: 36748513
doi: 10.1099/jgv.0.001814
pmc: PMC7614846
mid: EMS179319
doi:

Substances chimiques

Immunologic Factors 0
Viral Proteins 0
N1L protein, Vaccinia virus 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 090315
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M019810/1
Pays : United Kingdom

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Auteurs

Evgeniya V Shmeleva (EV)

Department of Pathology, University of Cambridge, Cambridge, UK.
Present address: Department of Biology, Tufts University, Medford, Massachusetts, USA.

Danial Syafiq (D)

Department of Pathology, University of Cambridge, Cambridge, UK.
Present address: Gonville and Caius College, University of Cambridge, Cambridge, UK.

Ana L Moldoveanu (AL)

Department of Pathology, University of Cambridge, Cambridge, UK.
Present address: Section of Microbiology, Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, UK.

Brian J Ferguson (BJ)

Department of Pathology, University of Cambridge, Cambridge, UK.

Geoffrey L Smith (GL)

Department of Pathology, University of Cambridge, Cambridge, UK.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ADN › Infections à Poxviridae › Vaccine › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Virus › Virus à ADN › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Virus de la vaccine › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Système tégumentaire › Peau › Suppression of innate immunity by the vaccinia...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Suppression of innate immunity by the vaccinia...