Mechanistic Insight into the Inhibition of Choline Acetyltransferase by Proton Pump Inhibitors.

Humans Proton Pump Inhibitors / pharmacology Choline O-Acetyltransferase / metabolism Alzheimer Disease / drug therapy Omeprazole / pharmacology Cholinergic Agents
Alzheimer’s disease MM-PBSA PET-ligands choline-acetyltransferase dementia molecular docking molecular dynamics neurodegenerative disorder proton pump inhibitors

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
15 02 2023
Historique:
pubmed: 8 2 2023
medline: 17 2 2023
entrez: 7 2 2023
Statut: ppublish

Résumé

Various pharmacoepidemiological investigational studies have indicated that Proton Pump Inhibitors (PPIs) may increase the likelihood of developing Alzheimer's disease (AD) and non-AD related dementias. Previously, we have reported the inhibition of the acetylcholine biosynthesizing enzyme choline acetyltransferase (ChAT) by PPIs, for which omeprazole, lansoprazole, and pantoprazole exhibited IC

Identifiants

DOI: 10.1021/acschemneuro.2c00738 PMID: 36749117
pubmed: 36749117
doi: 10.1021/acschemneuro.2c00738
doi:

Substances chimiques

Proton Pump Inhibitors 0
Choline O-Acetyltransferase EC 2.3.1.6
Omeprazole KG60484QX9
Cholinergic Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

749-765

Auteurs

Anurag T K Baidya (ATK)

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi, 221005 U.P., India.

Bhanuranjan Das (B)

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi, 221005 U.P., India.

Bharti Devi (B)

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi, 221005 U.P., India.

Bengt Långström (B)

Department of Chemistry, Uppsala University, SE-751 20 Uppsala, Sweden.

Hans Ågren (H)

Department of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.

Taher Darreh-Shori (T)

Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, NEO, Eighth Floor, 141 52 Stockholm, Sweden.

Rajnish Kumar (R)

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi, 221005 U.P., India.
ORCID: 0000-0002-7021-6996

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanistic Insight into the Inhibition of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la pompe à protons › Mechanistic Insight into the Inhibition of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acetyltransferases › Choline O-acetyltransferase › Mechanistic Insight into the Inhibition of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Mechanistic Insight into the Inhibition of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › (Pyridin-2-ylméthyl)sulfinyl-1H-benzimidazoles › Oméprazole › Mechanistic Insight into the Inhibition of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Mechanistic Insight into the Inhibition of...