Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
08 02 2023
08 02 2023
Historique:
entrez:
8
2
2023
pubmed:
9
2
2023
medline:
11
2
2023
Statut:
ppublish
Résumé
Preservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recipient matching, leading to donor heart underutilization. Here, we showed that metabolic reprogramming through up-regulation of the enzyme immune response gene 1 (IRG1) and its product itaconate improved heart function after prolonged preservation.
Identifiants
pubmed: 36753565
doi: 10.1126/scitranslmed.ade3782
pmc: PMC10068866
mid: NIHMS1879611
doi:
Substances chimiques
itaconic acid
Q4516562YH
Antioxidants
0
Valproic Acid
614OI1Z5WI
Histone Deacetylase Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eade3782Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL163672
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI132895
Pays : United States
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