Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease.

Humans Alzheimer Disease / drug therapy Butyrylcholinesterase / metabolism Amyloid beta-Peptides / metabolism Acetylcholinesterase / metabolism Cholinesterase Inhibitors / chemistry Molecular Structure Structure-Activity Relationship Neuroblastoma / drug therapy Drug Design Molecular Docking Simulation
AChE and BChE inhibition Alzheimer's disease Aβ and tau aggregation inhibition Multitarget-directed ligands (MTDLs) Thioxanthene-9-one and xanthen-9-one derivatives

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
15 Mar 2023
Historique:
received: 01 01 2023
revised: 27 01 2023
accepted: 28 01 2023
pubmed: 9 2 2023
medline: 16 3 2023
entrez: 8 2 2023
Statut: ppublish

Résumé

A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ

Identifiants

DOI: 10.1016/j.ejmech.2023.115169 PMID: 36753881
pubmed: 36753881
pii: S0223-5234(23)00084-3
doi: 10.1016/j.ejmech.2023.115169
pii:
doi:

Substances chimiques

Butyrylcholinesterase EC 3.1.1.8
Amyloid beta-Peptides 0
Acetylcholinesterase EC 3.1.1.7
Cholinesterase Inhibitors 0
2-(N-cyclohexylamino)ethanesulfonic acid 103-47-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115169

Informations de copyright

Copyright © 2023 Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Michele Tonelli (M)

Department of Pharmacy, University of Genoa, 16132, Genoa, Italy. Electronic address: michele.tonelli@unige.it.

Marco Catto (M)

Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 70125, Bari, Italy. Electronic address: marco.catto@uniba.it.

Raimon Sabaté (R)

Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028, Barcelona, Spain. Electronic address: rsabate@ub.edu.

Valeria Francesconi (V)

Department of Pharmacy, University of Genoa, 16132, Genoa, Italy.

Erik Laurini (E)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), Department of Engineering and Architecture, University of Trieste, 34127, Trieste, Italy.

Sabrina Pricl (S)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), Department of Engineering and Architecture, University of Trieste, 34127, Trieste, Italy; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236, Lodz, Poland.

Leonardo Pisani (L)

Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 70125, Bari, Italy.

Daniela Valeria Miniero (DV)

Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125, Bari, Italy.

Grazia Maria Liuzzi (GM)

Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125, Bari, Italy.

Elena Gatta (E)

Department of Physics, University of Genoa, 16146, Genoa, Italy.

Annalisa Relini (A)

Department of Physics, University of Genoa, 16146, Genoa, Italy.

Rosalina Gavín (R)

Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain; Institute of Neuroscience, University of Barcelona, 08028, Barcelona, Spain.

Jose Antonio Del Rio (JA)

Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028, Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain; Institute of Neuroscience, University of Barcelona, 08028, Barcelona, Spain.

Fabio Sparatore (F)

Department of Pharmacy, University of Genoa, 16132, Genoa, Italy.

Angelo Carotti (A)

Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 70125, Bari, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Thioxanthenone-based derivatives as...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Thioxanthenone-based derivatives as...