Echinacea purpurea (L.) Moench extract suppresses inflammation by inhibition of C3a/C3aR signaling pathway in TNBS-induced ulcerative colitis rats.

Animals Rats Colitis, Ulcerative / drug therapy Colon Echinacea Inflammation / pathology Signal Transduction Trinitrobenzenesulfonic Acid Complement C3a / metabolism
Echinacea purpurea (L.) Moench Medicinal plant Protective effect Ulcerative colitis

Journal

Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310

Informations de publication

Date de publication:
10 May 2023
Historique:
received: 20 10 2022
revised: 15 01 2023
accepted: 28 01 2023
pubmed: 9 2 2023
medline: 4 3 2023
entrez: 8 2 2023
Statut: ppublish

Résumé

Echinacea purpurea (L.) Moench (EP) is a perennial herbaceous flowering plant, commonly known as purple conical flower. It was widely used to treat skin inflammation and gastrointestinal diseases. Ulcerative colitis (UC) is a chronic and nonspecific inflammatory disease. Recent evidence shows that immune disorders are involved in the pathogenesis of UC. To evaluate the protective effect of Echinacea purpurea (L.) Moench exact (EE) on UC and explore the role of complement system in the treatment of UC. UC model was induced in rats by 2,4,6-trinitrobenzene sulfonic acid (TNBS), and then rats were administered with EE for 10 days. Collect colon tissues for analysis of relevant mechanisms. EE could reduce the weight loss and diarrhea of UC rats. In addition, EE could improve the integrity of intestinal epithelial barrier in UC rats. EE inhibited the level of proinflammatory cytokines and promoted the antioxidation. Furthermore, EE suppressed the expression of C3aR, CFB, CD55, TLR4 and NLRP3. These results indicate that EE may achieve therapeutic effect by inhibiting C3a/C3aR signal pathway, suggesting that EE may be used as a medicinal plant to alleviate UC.

Identifiants

DOI: 10.1016/j.jep.2023.116221 PMID: 36754188
pubmed: 36754188
pii: S0378-8741(23)00089-2
doi: 10.1016/j.jep.2023.116221
pii:
doi:

Substances chimiques

Trinitrobenzenesulfonic Acid 8T3HQG2ZC4
Complement C3a 80295-42-7
anaphylatoxin receptor C3a, rat 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

116221

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest We have no conflict of interest to declare.

Auteurs

Daxing Gu (D)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: guxxing@stu.scau.edu.cn.

Huiting Wang (H)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: wanghuiting@stu.scau.edu.cn.

Mingen Yan (M)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: yanmingen@stu.scau.edu.cn.

Yaoxing Li (Y)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: lyxing@stu.scau.edu.cn.

Shijing Yang (S)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: ysj@stu.scau.edu.cn.

Dayou Shi (D)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Nature Medicine, Guangzhou, 510642, China; International Institute of Traditional Chinese Veterinary Medicine, Guangzhou, 510642, China. Electronic address: shidayou@scau.edu.cn.

Shining Guo (S)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Nature Medicine, Guangzhou, 510642, China; International Institute of Traditional Chinese Veterinary Medicine, Guangzhou, 510642, China. Electronic address: shining@scau.edu.cn.

Li Wu (L)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Nature Medicine, Guangzhou, 510642, China; International Institute of Traditional Chinese Veterinary Medicine, Guangzhou, 510642, China. Electronic address: 30000924@scau.edu.cn.

Cui Liu (C)

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: liuc@scau.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Rectocolite hémorragique › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Echinacea › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Acides arènesulfoniques › Acide 2,4,6-trinitro-benzènesulfonique › Echinacea purpurea (L.) Moench extract...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complément C3 › Complément C3a › Echinacea purpurea (L.) Moench extract...