Anti-synthetase Syndrome That Relapsed with Pulmonary Arterial Hypertension and Malignancy.
anti-synthetase syndrome
interstitial lung disease
malignancy
polymyositis
pulmonary arterial hypertension
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Sep 2023
15 Sep 2023
Historique:
medline:
20
9
2023
pubmed:
9
2
2023
entrez:
8
2
2023
Statut:
ppublish
Résumé
A 69-year-old man with a history of anti-synthetase antibody-positive polymyositis and interstitial lung disease (ILD) stable for more than 20 years suddenly developed pulmonary artery hypertension (PAH) with a mean PA pressure of 46 mmHg. At this stage, ILD was mild, but it became acutely exacerbated later, and high-dose corticosteroid and intravenous cyclophosphamide ameliorated both PAH and ILD. The tricuspid regurgitation pressure gradient decreased from 80 to 49 mmHg and ILD recovered almost completely. During a systemic examination, bone metastatic cancer of unknown origin was found. We herein report the relationship between anti-synthetase syndrome (ASS) and PAH as well as ASS and malignancy.
Identifiants
pubmed: 36754403
doi: 10.2169/internalmedicine.1275-22
pmc: PMC10569925
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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