Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort.


Journal

Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564

Informations de publication

Date de publication:
23 03 2023
Historique:
pubmed: 10 2 2023
medline: 28 3 2023
entrez: 9 2 2023
Statut: ppublish

Résumé

While the goal of universal drug susceptibility testing has been a key component of the WHO End TB Strategy, in practice, this remains inaccessible to many. Rapid molecular tests for tuberculosis (TB) and antituberculosis drug resistance could significantly improve access to testing. In this study, we evaluated the accuracy of the Akonni Biosystems XDR-TB (extensively drug-resistant TB) TruArray and lateral-flow-cell (XDR-LFC) assay (Akonni Biosystems, Inc., Frederick, MD, USA), a novel assay that detects mutations in seven genes associated with resistance to antituberculosis drugs:

Identifiants

pubmed: 36757183
doi: 10.1128/jcm.01478-22
pmc: PMC10035299
doi:

Substances chimiques

Kanamycin 59-01-8
Isoniazid V83O1VOZ8L
Capreomycin 11003-38-6
Amikacin 84319SGC3C
Rifampin VJT6J7R4TR
Fluoroquinolones 0
Bacterial Proteins 0
Antitubercular Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0147822

Subventions

Organisme : NIAID NIH HHS
ID : R44 AI138903
Pays : United States
Organisme : NIGMS NIH HHS
ID : R44 GM103053
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135756
Pays : United States
Organisme : NIBIB NIH HHS
ID : R44 EB011274
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007384
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111435
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201600024C
Pays : United States

Références

N Engl J Med. 2010 Sep 9;363(11):1005-15
pubmed: 20825313
Am J Respir Crit Care Med. 2019 Mar 15;199(6):784-794
pubmed: 30252496
J Clin Microbiol. 2021 Feb 18;59(3):
pubmed: 33298611
J Clin Microbiol. 2020 Oct 21;58(11):
pubmed: 32817085
J Clin Microbiol. 2018 Feb 22;56(3):
pubmed: 29305543
Eur Respir J. 2020 Sep 17;56(3):
pubmed: 32430421
J Clin Microbiol. 2018 Apr 25;56(5):
pubmed: 29540456
J Infect Dis. 2019 Oct 8;220(220 Suppl 3):S126-S135
pubmed: 31593599
Anal Chem. 2020 Apr 7;92(7):5311-5318
pubmed: 32142258
J Clin Tuberc Other Mycobact Dis. 2022 Feb 22;27:100304
pubmed: 35252594
BMC Microbiol. 2015 Oct 19;15:220
pubmed: 26483194
J Virol Methods. 2014 Nov;208:152-9
pubmed: 25066276
Biomed Microdevices. 2012 Feb;14(1):45-53
pubmed: 21909803
N Engl J Med. 2018 Oct 11;379(15):1403-1415
pubmed: 30280646
PLoS One. 2018 Jul 5;13(7):e0199869
pubmed: 29975759
Lab Chip. 2019 Mar 27;19(7):1217-1225
pubmed: 30801596
JMIR Res Protoc. 2021 Jul 14;10(7):e26748
pubmed: 34259165
Clin Infect Dis. 2016 May 1;62(9):1081-8
pubmed: 26839383
Lancet Microbe. 2022 Apr;3(4):e265-e273
pubmed: 35373160
Genome Med. 2019 Jun 24;11(1):41
pubmed: 31234910

Auteurs

Rehan R Syed (RR)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Donald G Catanzaro (DG)

Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA.

Rebecca E Colman (RE)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Christopher G Cooney (CG)

Akonni Biosystems, Inc., Frederick, Maryland, USA.

Yvonne Linger (Y)

Akonni Biosystems, Inc., Frederick, Maryland, USA.

Alexander V Kukhtin (AV)

Akonni Biosystems, Inc., Frederick, Maryland, USA.

Rebecca C Holmberg (RC)

Akonni Biosystems, Inc., Frederick, Maryland, USA.

Ryan Norville (R)

Akonni Biosystems, Inc., Frederick, Maryland, USA.

Valeriu Crudu (V)

Phthisiopneumology Institute, Chișinău, Republic of Moldova.

Nelly Ciobanu (N)

Phthisiopneumology Institute, Chișinău, Republic of Moldova.

Alexandru Codreanu (A)

Phthisiopneumology Institute, Chișinău, Republic of Moldova.

Marva Seifert (M)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Naomi Hillery (N)

Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.

Peter Chiles (P)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Antonino Catanzaro (A)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Timothy C Rodwell (TC)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

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Classifications MeSH