Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel.
Journal
Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060
Informations de publication
Date de publication:
27 02 2023
27 02 2023
Historique:
pubmed:
10
2
2023
medline:
3
3
2023
entrez:
9
2
2023
Statut:
ppublish
Résumé
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are neurotransmitter-activated cation channels ubiquitously expressed in vertebrate brains. The regulation of calcium flux through the channel pore by RNA-editing is linked to synaptic plasticity while excessive calcium influx poses a risk for neurodegeneration. Unfortunately, the molecular mechanisms underlying this key process are mostly unknown. Here, we investigated calcium conduction in calcium-permeable AMPAR using Molecular Dynamics (MD) simulations with recently introduced multisite force-field parameters for Ca
Identifiants
pubmed: 36758214
doi: 10.1021/acs.jcim.2c01494
pmc: PMC9976283
doi:
Substances chimiques
Calcium
SY7Q814VUP
Receptors, Glutamate
0
Ion Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1293-1300Références
Chemistry. 2013 Feb 25;19(9):3047-60
pubmed: 23315704
Chemphyschem. 2005 Sep 5;6(9):1715-8
pubmed: 16080223
Nat Commun. 2018 Feb 19;9(1):717
pubmed: 29459730
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Neuron. 1995 Jul;15(1):193-204
pubmed: 7619522
Acta Crystallogr D Struct Biol. 2019 Oct 1;75(Pt 10):861-877
pubmed: 31588918
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3454-9
pubmed: 24550503
J Chem Theory Comput. 2019 Jun 11;15(6):3810-3823
pubmed: 30998344
J Phys Chem Lett. 2021 May 6;12(17):4286-4291
pubmed: 33909426
Proteins. 2010 Jun;78(8):1950-8
pubmed: 20408171
J Physiol. 1995 Jun 1;485 ( Pt 2):403-18
pubmed: 7666365
Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):
pubmed: 33602810
J Chem Theory Comput. 2012 May 8;8(5):1629-40
pubmed: 26593656
J Am Chem Soc. 2001 Jan 24;123(3):431-41
pubmed: 11456545
J Am Chem Soc. 2021 Aug 11;143(31):12181-12193
pubmed: 34323472
Nature. 2017 Sep 7;549(7670):60-65
pubmed: 28737760
Biophys Chem. 2006 Dec 1;124(3):292-301
pubmed: 16737771
Nat Commun. 2013;4:2721
pubmed: 24217363
R Soc Open Sci. 2017 Jan 4;4(1):160671
pubmed: 28280569
Nat Commun. 2020 Feb 17;11(1):922
pubmed: 32066742
J Chem Phys. 2007 Aug 21;127(7):074503
pubmed: 17718616
J Gen Physiol. 1988 Jul;92(1):1-26
pubmed: 2459298
J Chem Phys. 2014 Aug 28;141(8):084502
pubmed: 25173016
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3619-28
pubmed: 26100907
Phys Rev B Condens Matter. 1988 Jan 15;37(2):785-789
pubmed: 9944570
Nat Chem. 2018 Aug;10(8):813-820
pubmed: 30030538
J Am Chem Soc. 2004 Feb 4;126(4):1020-1
pubmed: 14746460
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):592-7
pubmed: 21187429
J Phys Chem B. 2016 Mar 3;120(8):1885-93
pubmed: 26788746
Cell Mol Life Sci. 2021 Jul;78(14):5605-5630
pubmed: 34100982
J Am Chem Soc. 2012 Jan 25;134(3):1840-6
pubmed: 22191670
Neuron. 1992 Jan;8(1):189-98
pubmed: 1370372
J Mol Biol. 2023 Jan 20;435(6):167970
pubmed: 36682679
J Phys Chem B. 2010 Mar 4;114(8):2549-64
pubmed: 20136072
Proc Natl Acad Sci U S A. 2018 May 22;115(21):5450-5455
pubmed: 29735669
J Am Chem Soc. 2020 May 20;142(20):9415-9427
pubmed: 32336093
Neuron. 2006 Mar 2;49(5):719-33
pubmed: 16504947
J Chem Phys. 2019 Apr 28;150(16):164120
pubmed: 31042914
Front Mol Biosci. 2020 Mar 20;7:45
pubmed: 32266290
J Physiol. 2019 Feb;597(3):679-698
pubmed: 30471114
Science. 1991 May 10;252(5007):851-3
pubmed: 1709304
Annu Rev Biophys Biomol Struct. 2005;34:153-71
pubmed: 15869387
J Mol Biol. 2007 Feb 16;366(2):687-701
pubmed: 17174326
Chemphyschem. 2017 Oct 6;18(19):2807-2811
pubmed: 28510283
Neuron. 2016 Mar 2;89(5):1000-15
pubmed: 26938443
Phys Rev A Gen Phys. 1988 Sep 15;38(6):3098-3100
pubmed: 9900728
Science. 1991 Jun 21;252(5013):1715-8
pubmed: 1710829
Cell. 2016 Sep 22;167(1):145-157.e17
pubmed: 27662087
Chem Rev. 2019 Jul 10;119(13):7737-7832
pubmed: 31246417
Biophys J. 2011 Aug 17;101(4):809-17
pubmed: 21843471
J Phys Chem Lett. 2021 Oct 7;12(39):9449-9454
pubmed: 34555284
J Chem Theory Comput. 2019 Oct 8;15(10):5601-5613
pubmed: 31498615
Nature. 2009 Dec 10;462(7274):745-56
pubmed: 19946266
J Chem Theory Comput. 2021 Mar 9;17(3):1726-1741
pubmed: 33539082
Nature. 2021 Jun;594(7863):454-458
pubmed: 34079129
J Comput Chem. 2013 Sep 30;34(25):2135-45
pubmed: 23832629
Chem Rev. 2016 May 11;116(9):4983-5013
pubmed: 26815602
Cell. 2017 Sep 7;170(6):1234-1246.e14
pubmed: 28823560
Pharmacol Rev. 2021 Oct;73(4):298-487
pubmed: 34753794
J Phys Chem Lett. 2020 Aug 6;11(15):6373-6381
pubmed: 32672983