Inflammation, stress and depression: An exploration of ketamine's therapeutic profile.

Animals Depression / drug therapy Ketamine / pharmacology Antidepressive Agents / pharmacology Inflammation / drug therapy Anti-Inflammatory Agents / pharmacology
Ketamine anhedonia depression inflammation stress treatment-resistant depression

Journal

Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391

Informations de publication

Date de publication:
04 2023
Historique:
received: 23 09 2022
revised: 13 12 2022
accepted: 31 01 2023
pmc-release: 01 04 2024
medline: 30 3 2023
pubmed: 10 2 2023
entrez: 9 2 2023
Statut: ppublish

Résumé

Well-established animal models of depression have described a proximal relationship between stress and central nervous system (CNS) inflammation - a relationship mirrored in the peripheral inflammatory biomarkers of individuals with depression. Evidence also suggests that stress-induced proinflammatory states can contribute to the neurobiology of treatment-resistant depression. Interestingly, ketamine, a rapid-acting antidepressant, can partially exert its therapeutic effects via anti-inflammatory actions on the hypothalamic-pituitary adrenal (HPA) axis, the kynurenine pathway or by cytokine suppression. Further investigations into the relationship between ketamine, inflammation and stress could provide insight into ketamine's unique therapeutic mechanisms and stimulate efforts to develop rapid-acting, anti-inflammatory-based antidepressants.

Identifiants

DOI: 10.1016/j.drudis.2023.103518 PMID: 36758932 PMC: PMC10050119
pubmed: 36758932
pii: S1359-6446(23)00034-X
doi: 10.1016/j.drudis.2023.103518
pmc: PMC10050119
mid: NIHMS1872725
pii:
doi:

Substances chimiques

Ketamine 690G0D6V8H
Antidepressive Agents 0
Anti-Inflammatory Agents 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

103518

Subventions

Organisme : Intramural NIH HHS
ID : ZIA MH002857
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

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Auteurs

Jenessa N Johnston (JN)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address: johnstonjenessa@gmail.com.

Maximillian S Greenwald (MS)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Ioline D Henter (ID)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Christoph Kraus (C)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Anahit Mkrtchian (A)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Neil G Clark (NG)

US School of Medicine, Uniformed Services University, Bethesda, MD, USA.

Lawrence T Park (LT)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Philip Gold (P)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Carlos A Zarate (CA)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Bashkim Kadriu (B)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inflammation, stress and depression: An...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Inflammation, stress and depression: An...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclohexanes › Kétamine › Inflammation, stress and depression: An...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Antidépresseurs › Inflammation, stress and depression: An...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Inflammation, stress and depression: An...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Inflammation, stress and depression: An...