Prognostic Significance of a Model Based on Acetaldehyde Dehydrogenase 2 Genetic Polymorphisms in Laryngeal Carcinoma.
acetaldehyde dehydrogenase 2
fibrinogen
hemoglobin
laryngeal carcinoma
nomogram
polymorphism
Journal
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
ISSN: 1097-6817
Titre abrégé: Otolaryngol Head Neck Surg
Pays: England
ID NLM: 8508176
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
28
11
2022
received:
07
08
2022
accepted:
03
12
2022
medline:
28
8
2023
pubmed:
10
2
2023
entrez:
9
2
2023
Statut:
ppublish
Résumé
Because of the high costs associated with early-stage laryngeal carcinoma diagnosis and prognosis prediction, this study attempts to find valuable targets to establish a novel predictive model by focusing on the aldehyde dehydrogenase 2 (ALDH2) genotype and other peripheral blood markers. Retrospective study. Tertiary comprehensive hospital. From January 2011 to January 2021, 362 cases of laryngeal carcinoma were included and divided into 2 groups in this retrospective analysis. Information on medical history, alcohol, and tobacco consumption habits, ALDH2 genotypes, and other peripheral blood markers was collected. Endpoints of the current study included disease-free survival and overall survival. A nomogram model for overall survival was established and evaluated using receiver operating characteristic (ROC) curves. A total of 236 patients were included in the training cohort, and the other 126 were included in the validation cohort. The median follow-up of the patients was 9.6 years (interquartile range: 7.5-12.5 years). Peripheral fibrinogen, hemoglobin, and ALDH2 genotypes were significantly associated with an increase in laryngeal carcinoma mortality rate on Kaplan-Meier curves. The ROC curve showed that the effectiveness of overall survival prediction by the nomogram model was better than that of traditional clinical staging. A prognostic nomogram of laryngeal carcinoma patients involving ALDH2 and peripheral blood markers and T and N stages was constructed and validated.
Substances chimiques
aldehyde dehydrogenase (NAD(P)+)
EC 1.2.1.5
Aldehyde Dehydrogenase, Mitochondrial
EC 1.2.1.3
Acetaldehyde
GO1N1ZPR3B
ALDH2 protein, human
EC 1.2.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
528-538Informations de copyright
© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.
Références
Karatzanis AD, Psychogios G, Waldfahrer F, et al. Management of locally advanced laryngeal cancer. J Otolaryngol Head Neck Surg. 2014;43:4. doi:10.1186/1916-0216-43-4
Megwalu UC, Sikora AG. Survival outcomes in advanced laryngeal cancer. JAMA Otolaryngol Head Neck Surg. 2014;140(9):855-860. doi:10.1001/jamaoto.2014.1671
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin. 2017;67(1):31-50. doi:10.3322/caac.21386
Yoval-Sánchez B, Rodríguez-Zavala JS. Differences in susceptibility to inactivation of human aldehyde dehydrogenases by lipid peroxidation byproducts. Chem Res Toxicol. 2012;25(3):722-729. doi:10.1021/tx2005184
Colevas AD, Yom SS, Pfister DG, et al. NCCN guidelines insights: head and neck cancers, version 1.2018. J Natl Compr Canc Netw. 2018;16(5):479-490. doi:10.6004/jnccn.2018.0026
Daquan W, Tian W, Shen N, Danzheng L, Xinsheng H. Decrement of prognostic nutrition index in laryngeal diseases: from precancerous lesion to squamous cell carcinoma. Acta Otolaryngol. 2021;141(12):1070-1074. doi:10.1080/00016489.2019.1634836
Song G, Liu H. Effect of Hospital to Home nutrition management model on postoperative clinical outcomes of patients with laryngeal carcinoma. Oncol Lett. 2017;14(4):4059-4064. doi:10.3892/ol.2017.6709
León-Idougourram S, Pérez-Gómez JM, Muñoz Jiménez C, et al. Morphofunctional and molecular assessment of nutritional status in head and neck cancer patients undergoing systemic treatment: role of inflammasome in clinical nutrition. Cancers (Basel). 2022;14(3):494. doi:10.3390/cancers14030494
Cai H, Zhang ZH, Zhou YJ, Liu J, Chen HQ, Lin RY. The prognostic value of preoperative plasma fibrinogen and neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Ear Nose Throat J. 2021;100(10):731-736. doi:10.1177/0145561320920746
Zhao Y, Qin J, Qiu Z, Guo J, Chang W. Prognostic role of neutrophil-to-lymphocyte ratio to laryngeal squamous cell carcinoma: a meta-analysis. Braz J Otorhinolaryngol. 2020;88:717-724. doi:10.1016/j.bjorl.2020.09.015
Ye J, Liao B, Jiang X, et al. Prognosis value of platelet counts, albumin and neutrophil-lymphocyte ratio of locoregional recurrence in patients with operable head and neck squamous cell carcinoma. Cancer Manag Res. 2020;12:731-741. doi:10.2147/cmar.S234618
Shen LF, Wang QY, Yu Q. The systemic immune-inflammation index and albumin as prognostic predictors in laryngeal carcinoma. Nutr Cancer. 2021;73(10):1916-1923. doi:10.1080/01635581.2020.1812677
Marchi F, Missale F, Incandela F, et al. Prognostic significance of peripheral T-cell subsets in laryngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol. 2019;4(5):513-519. doi:10.1002/lio2.304
LoConte NK, Brewster AM, Kaur JS, Merrill JK, Alberg AJ. Alcohol and cancer: a statement of the American Society of Clinical Oncology. J Clin Oncol. 2018;36(1):83-93. doi:10.1200/JCO.2017.76.1155
Han P, Li Y, Liang F, et al. Polymorphisms of acetaldehyde dehydrogenase 2 and alcohol dehydrogenase 1B on the malignant transformation of vocal cord leukoplakia: a Chinese cohort. Mol Carcinog. 2022;61(5):472-480. doi:10.1002/mc.23391
Jenckel F, Knecht R. State of the art in the treatment of laryngeal cancer. Anticancer Res. 2013;33(11):4701-4710.
Kim DY, Kim IS, Park SG, Kim H, Choi YJ, Seol YM. Prognostic value of posttreatment neutrophil-lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy. Auris Nasus Larynx. 2017;44(2):199-204. doi:10.1016/j.anl.2016.05.013
Kawakita D, Oze I, Hosono S, et al. Prognostic value of drinking status and aldehyde dehydrogenase 2 polymorphism in patients with head and neck squamous cell carcinoma. J Epidemiol. 2016;26(6):292-299. doi:10.2188/jea.JE20140240
Huang CC, Hsiao JR, Lee WT, et al. Investigating the association between alcohol and risk of head and neck cancer in Taiwan. Sci Rep. 2017;7(1):9701. doi:10.1038/s41598-017-08802-4
Serio RN, Lu C, Gross SS, Gudas LJ. Different effects of knockouts in ALDH2 and ACSS2 on embryonic stem cell differentiation. Alcohol Clin Exp Res. 2019;43(9):1859-1871. doi:10.1111/acer.14146
Chen L, Wu M, Ji C, Yuan M, Liu C, Yin Q. Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2. IUBMB Life. 2020;72(2):285-295. doi:10.1002/iub.2166
Cui J, Wang L, Zhong W, et al. Development and validation of epigenetic signature predict survival for patients with laryngeal squamous cell carcinoma. DNA Cell Biol. 2021;40(2):247-264. doi:10.1089/dna.2020.5789
Bagnardi V, Rota M, Botteri E, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer. 2015;112(3):580-593. doi:10.1038/bjc.2014.579
Bagnardi V, Rota M, Botteri E, et al. Light alcohol drinking and cancer: a meta-analysis. Ann Oncol. 2013;24(2):301-308. doi:10.1093/annonc/mds337
Meng L, Song Z, Liu A, Dahmen U, Yang X, Fang H. Effects of lipopolysaccharide-binding protein (LBP) single nucleotide polymorphism (SNP) in infections, inflammatory diseases, metabolic disorders and cancers. Front Immunol. 2021;12:681810. doi:10.3389/fimmu.2021.681810
Hopkins RJ, Duan F, Gamble GD, et al. Chr15q25 genetic variant (rs16969968) independently confers risk of lung cancer, COPD and smoking intensity in a prospective study of high-risk smokers. Thorax. 2021;76(3):272-280. doi:10.1136/thoraxjnl-2020-214839
Fanfani V, Zatopkova M, Harris AL, Pezzella F, Stracquadanio G. Dissecting the heritable risk of breast cancer: from statistical methods to susceptibility genes. Sem Cancer Biol. 2021;72:175-184. doi:10.1016/j.semcancer.2020.06.001
Lee WT, Hsiao JR, Ou CY, et al. The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients. Cancer Epidemiol Biomarkers Prev. 2019;28(2):248-257. doi:10.1158/1055-9965.Epi-18-0425
Huang HY, Lau HC, Ji MY, Hsueh CY, Zhang M. Association between alcohol dehydrogenase polymorphisms and the recurrence of laryngeal carcinoma. Laryngoscope. 2022;132:2169-2176. doi:10.1002/lary.30083
Zhang H, Fu L. The role of ALDH2 in tumorigenesis and tumor progression: targeting ALDH2 as a potential cancer treatment. Acta Pharm Sin B. 2021;11(6):1400-1411. doi:10.1016/j.apsb.2021.02.008
Guo YM, Chen JR, Feng YC, et al. Germline polymorphisms and length of survival of nasopharyngeal carcinoma: an exome-wide association study in multiple cohorts. Adv Sci (Weinh). 2020;7(10):1903727. doi:10.1002/advs.201903727
Avinçsal MO, Shinomiya H, Teshima M, et al. Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer. Head Neck. 2018;40(4):770-777. doi:10.1002/hed.25050
Sheng L, Luo M, Sun X, Lin N, Mao W, Su D. Serum fibrinogen is an independent prognostic factor in operable nonsmall cell lung cancer. Int J Cancer. 2013;133(11):2720-2725. doi:10.1002/ijc.28284
Wu M, Pan Y, Jia Z, et al. Preoperative plasma fibrinogen and serum albumin score is an independent prognostic factor for resectable stage II-III gastric cancer. Dis Markers. 2019;2019:9060845. doi:10.1155/2019/9060845
Sheng X, Zhang H, Ge P, Chen L, Zhang S. A retrospective study of the prognostic significance of preoperative plasma fibrinogen, mean platelet volume, and the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Med Sci Monit. 2019;25:4527-4534. doi:10.12659/msm.914426
Gorphe P, Bouhir S, Garcia GCTE, et al. Anemia and neutrophil-to-lymphocyte ratio in laryngeal cancer treated with induction chemotherapy. Laryngoscope. 2020;130(4):E144-E150. doi:10.1002/lary.28021
Narayanasamy RK, Muthusekar RM, Nagalingam SP, Thyagarajan S, Ramakrishnan B, Perumal K. Lower pretreatment hemoglobin status and treatment breaks in locally advanced head and neck squamous cell carcinoma during concurrent chemoradiation. Indian J Cancer. 2021;58(1):62-68. doi:10.4103/ijc.IJC_656_18
Cui J, Wang L, Tan G, et al. Development and validation of nomograms to accurately predict risk of recurrence for patients with laryngeal squamous cell carcinoma: cohort study. Int J Surg. 2020;76:163-170. doi:10.1016/j.ijsu.2020.03.010
Eskiizmir G, Baskın Y, Yalçın F, Ellidokuz H, Ferris RL. Risk factors for radiation failure in early-stage glottic carcinoma: a systematic review and meta-analysis. Oral Oncol. 2016;62:90-100. doi:10.1016/j.oraloncology.2016.10.013
Egelmeer AGTM, Velazquez ER, de Jong JMA, et al. Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: a cohort study based on 994 patients. Radiother Oncol. 2011;100(1):108-115. doi:10.1016/j.radonc.2011.06.023