CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
17 02 2023
17 02 2023
Historique:
pmc-release:
17
02
2024
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
15
2
2023
Statut:
ppublish
Résumé
Passive transfer of broadly neutralizing anti-HIV-1 antibodies (bNAbs) protects against infection, and therefore, eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. bNAbs that target the CD4 binding site (CD4bs) on HIV-1 Env are among the most broadly active, but to date, responses elicited against this epitope in vaccinated animals have lacked potency and breadth. We hypothesized that CD4bs bNAbs resembling the antibody IOMA might be easier to elicit than other CD4bs antibodies that exhibit higher somatic mutation rates, a difficult-to-achieve mechanism to accommodate Env's N276
Identifiants
pubmed: 36763635
doi: 10.1126/sciimmunol.ade6364
pmc: PMC10202037
mid: NIHMS1887584
doi:
Substances chimiques
Broadly Neutralizing Antibodies
0
Antibodies, Neutralizing
0
HIV Antibodies
0
CD4 Antigens
0
Epitopes
0
Cell Adhesion Molecules
0
Polysaccharides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
eade6364Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI144462
Pays : United States
Organisme : NIAID NIH HHS
ID : P50 AI150464
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI100148
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI127249
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI138212
Pays : United States
Références
PLoS Pathog. 2013 Jan;9(1):e1003106
pubmed: 23300456
AIDS Res Hum Retroviruses. 1992 Aug;8(8):1515
pubmed: 1466993
Nature. 1998 Jun 18;393(6686):648-59
pubmed: 9641677
J Virol. 2001 Sep;75(17):8340-7
pubmed: 11483779
Nat Protoc. 2006;1(2):755-68
pubmed: 17406305
Science. 2015 Jul 10;349(6244):156-61
pubmed: 26089355
Lancet Microbe. 2021 Mar;2(3):e95
pubmed: 35544160
Nat Commun. 2022 Aug 3;13(1):4515
pubmed: 35922441
J Virol. 1999 May;73(5):4009-18
pubmed: 10196297
Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26523-26533
pubmed: 31822621
Cell. 2016 Sep 8;166(6):1471-1484.e18
pubmed: 27610571
Science. 2016 Mar 25;351(6280):1458-63
pubmed: 27013733
Science. 2013 May 10;340(6133):711-6
pubmed: 23539181
Nature. 2011 Nov 30;481(7379):81-4
pubmed: 22139420
Sci Transl Med. 2021 Nov 24;13(621):eabk1533
pubmed: 34818054
J Virol. 2011 Aug;85(16):8270-84
pubmed: 21653661
Cell. 2015 Jun 18;161(7):1505-15
pubmed: 26091035
Angew Chem Int Ed Engl. 2021 Jan 4;60(1):321-330
pubmed: 32886840
Nat Med. 2000 Feb;6(2):200-6
pubmed: 10655110
Mol Syst Biol. 2011 Oct 11;7:539
pubmed: 21988835
Biotechniques. 2019 Jun;66(6):254-259
pubmed: 31124712
Nucleic Acids Res. 2000 Jan 1;28(1):214-8
pubmed: 10592229
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Nature. 2019 Jun;570(7762):468-473
pubmed: 31142836
Front Immunol. 2021 Aug 09;12:709240
pubmed: 34434193
Cell. 2016 Sep 8;166(6):1459-1470.e11
pubmed: 27610570
Sci Adv. 2022 Aug 12;8(32):eabp8155
pubmed: 35960796
Science. 2021 Feb 12;371(6530):735-741
pubmed: 33436524
Immunity. 1997 Dec;7(6):765-75
pubmed: 9430222
Nat Med. 2021 Dec;27(12):2234-2245
pubmed: 34887575
Sci Rep. 2016 Jan 19;6:19234
pubmed: 26781591
Biochem Biophys Res Commun. 2009 Dec 18;390(3):404-9
pubmed: 19748484
Curr Opin Virol. 2021 Dec;51:172-178
pubmed: 34742037
Cell. 2013 Mar 28;153(1):126-38
pubmed: 23540694
Front Immunol. 2017 May 10;8:537
pubmed: 28539926
Nat Struct Mol Biol. 2016 Oct;23(10):906-915
pubmed: 27617431
Comput Struct Biotechnol J. 2015 Nov 26;14:58-68
pubmed: 26862374
Virus Res. 2012 Nov;169(2):415-29
pubmed: 22728444
Cell Rep. 2019 Dec 3;29(10):3060-3072.e7
pubmed: 31801073
PLoS One. 2021 Mar 4;16(3):e0247963
pubmed: 33661993
Methods Mol Biol. 2009;485:395-405
pubmed: 19020839
PLoS Pathog. 2014 Aug 28;10(8):e1004337
pubmed: 25166308
Nat Commun. 2022 Oct 17;13(1):6123
pubmed: 36253376
Science. 2019 Dec 6;366(6470):
pubmed: 31806786
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W503-8
pubmed: 18503082
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2083-90
pubmed: 22745174
Cell Rep. 2021 May 4;35(5):109084
pubmed: 33951425
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15859-64
pubmed: 23019371
Nat Rev Genet. 2015 Jul;16(7):379-94
pubmed: 26055155
Sci Immunol. 2021 Dec 03;6(66):eabf1152
pubmed: 34860581
Cell Rep. 2017 Apr 25;19(4):669-670
pubmed: 28445718
Nature. 2019 Feb;566(7744):398-402
pubmed: 30760926
Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E690-7
pubmed: 22366317
Sci Transl Med. 2021 Jan 20;13(577):
pubmed: 33288661
J Virol. 2010 Feb;84(3):1302-13
pubmed: 19906907
Immunity. 2018 Aug 21;49(2):301-311.e5
pubmed: 30076101
Front Immunol. 2021 Oct 19;12:708227
pubmed: 34737737
Cell. 2018 Jun 14;173(7):1783-1795.e14
pubmed: 29731169
Immunol Rev. 2017 Jan;275(1):11-20
pubmed: 28133814
Bioinformatics. 2017 May 1;33(9):1405-1406
pubmed: 28453672
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Science. 2011 Sep 16;333(6049):1633-7
pubmed: 21764753
Methods Mol Biol. 2009;504:351-83
pubmed: 19159106
Cell Rep. 2019 Nov 12;29(7):1756-1766.e8
pubmed: 31722194
PLoS Pathog. 2013 Sep;9(9):e1003618
pubmed: 24068931
Nat Immunol. 2019 Mar;20(3):362-372
pubmed: 30742080
Immunity. 2018 Apr 17;48(4):799-811.e9
pubmed: 29669253
J Gen Virol. 2001 May;82(Pt 5):1013-1025
pubmed: 11297676
J Virol. 2011 Oct;85(19):9998-10009
pubmed: 21795340
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18921-5
pubmed: 23100539
Immunity. 2021 Feb 9;54(2):324-339.e8
pubmed: 33453152
Curr Opin Struct Biol. 2007 Aug;17(4):467-73
pubmed: 17870469
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Science. 2014 Dec 12;346(6215):1380-1383
pubmed: 25504724
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3268-77
pubmed: 23115339
J Virol. 2014 Mar;88(5):2489-507
pubmed: 24352443
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W34-40
pubmed: 23671333
Front Immunol. 2019 Oct 09;10:2365
pubmed: 31649674
Immunity. 2018 Dec 18;49(6):1162-1174.e8
pubmed: 30552024
PLoS Pathog. 2009 May;5(5):e1000433
pubmed: 19436712
J Exp Med. 2013 Apr 8;210(4):655-63
pubmed: 23530120
ACS Nano. 2018 Sep 25;12(9):8855-8866
pubmed: 30028591
Immunity. 2013 Aug 22;39(2):245-58
pubmed: 23911655
N Engl J Med. 2021 Mar 18;384(11):1003-1014
pubmed: 33730454
STAR Protoc. 2021 Mar 15;2(2):100389
pubmed: 33778783
Cell Rep. 2016 Aug 30;16(9):2327-38
pubmed: 27545891
Curr Opin Struct Biol. 2004 Oct;14(5):601-6
pubmed: 15465322
Cell Rep. 2016 Mar 22;14(11):2695-706
pubmed: 26972002
Science. 2010 Aug 13;329(5993):811-7
pubmed: 20616231
Cell Rep. 2014 May 8;7(3):785-95
pubmed: 24767986
Nature. 1992 Feb 20;355(6362):728-30
pubmed: 1741059
Nature. 2014 May 1;509(7498):55-62
pubmed: 24590074
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
Nat Commun. 2016 Feb 24;7:10618
pubmed: 26907590
Nat Med. 2000 Feb;6(2):207-10
pubmed: 10655111
Cell. 2015 Sep 10;162(6):1379-90
pubmed: 26359989
Elife. 2016 Mar 21;5:
pubmed: 26997349
Nat Immunol. 2002 Apr;3(4):399-406
pubmed: 11896394
Immunity. 2018 Aug 21;49(2):288-300.e8
pubmed: 30097292
Cell. 2014 Feb 13;156(4):633-48
pubmed: 24529371
Front Immunol. 2019 May 01;10:956
pubmed: 31118935
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774
J Exp Med. 2019 Jun 3;216(6):1301-1310
pubmed: 30975893
Science. 2010 Aug 13;329(5993):856-61
pubmed: 20616233
Nat Med. 2009 Aug;15(8):951-4
pubmed: 19525965
Nat Med. 1999 Feb;5(2):204-10
pubmed: 9930869
Curr Protoc Immunol. 2005 Jan;Chapter 12:12.11.1-12.11.17
pubmed: 18432938
J Exp Med. 2019 Oct 7;216(10):2316-2330
pubmed: 31345931
Immunity. 2019 Jul 16;51(1):141-154.e6
pubmed: 31315032