Long-term exposure to traffic noise and risk of incident colon cancer: A pooled study of eleven Nordic cohorts.

Humans Noise, Transportation Cohort Studies Risk Factors Air Pollution Colonic Neoplasms Environmental Exposure / analysis Denmark / epidemiology

Colon cancer Distal Pooled cohort study Proximal Railway noise Road traffic noise

Journal

Environmental research

ISSN: 1096-0953

Titre abrégé: Environ Res

Pays: Netherlands

ID NLM: 0147621

Informations de publication

Date de publication:
01 05 2023

Historique:

received: 04 01 2023

revised: 31 01 2023

accepted: 08 02 2023

pubmed: 11 2 2023

medline: 15 3 2023

entrez: 10 2 2023

Statut: ppublish

Résumé

Background Colon cancer incidence is rising globally, and factors pertaining to urbanization have been proposed involved in this development. Traffic noise may increase colon cancer risk by causing sleep disturbance and stress, thereby inducing known colon cancer risk-factors, e.g. obesity, diabetes, physical inactivity, and alcohol consumption, but few studies have examined this. Objectives The objective of this study was to investigate the association between traffic noise and colon cancer (all, proximal, distal) in a pooled population of 11 Nordic cohorts, totaling 155,203 persons. Methods We identified residential address history and estimated road, railway, and aircraft noise, as well as air pollution, for all addresses, using similar exposure models across cohorts. Colon cancer cases were identified through national registries. We analyzed data using Cox Proportional Hazards Models, adjusting main models for harmonized sociodemographic and lifestyle data. Results During follow-up (median 18.8 years), 2757 colon cancer cases developed. We found a hazard ratio (HR) of 1.05 (95% confidence interval (CI): 0.99-1.10) per 10-dB higher 5-year mean time-weighted road traffic noise. In sub-type analyses, the association seemed confined to distal colon cancer: HR 1.06 (95% CI: 0.98-1.14). Railway and aircraft noise was not associated with colon cancer, albeit there was some indication in sub-type analyses that railway noise may also be associated with distal colon cancer. In interaction-analyses, the association between road traffic noise and colon cancer was strongest among obese persons and those with high NO

Identifiants

DOI: 10.1016/j.envres.2023.115454 PMID: 36764429

pubmed: 36764429

pii: S0013-9351(23)00246-3

doi: 10.1016/j.envres.2023.115454

pii:

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

115454

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.