Rational design of HJH antimicrobial peptides to improve antimicrobial activity.

Antimicrobial Cationic Peptides / pharmacology Antimicrobial Peptides Cell Membrane Drug Resistance, Microbial Anti-Infective Agents / pharmacology Microbial Sensitivity Tests Anti-Bacterial Agents / pharmacology
Antimicrobial activity Antimicrobial peptides HJH-1

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
01 03 2023
Historique:
received: 02 01 2023
revised: 01 02 2023
accepted: 05 02 2023
pubmed: 11 2 2023
medline: 3 3 2023
entrez: 10 2 2023
Statut: ppublish

Résumé

Antimicrobial peptides (AMPs) have attracted considerable interest in the past decade due to their advantages for tackling antibiotic resistance. They exhibit potential antimicrobial activity through unique cell membrane destruction mechanism based on their net charge, hydrophobic properties, and α-helix. In this work, a series of HJH peptides was rationally designed and synthesized. The antimicrobial activity and cytotoxicity assays indicated that HJH-5 and HJH-6 containing hydrophobic residues and helices displayed prominent antimicrobial activity and mild cytotoxicity, respectively. These peptides may be developed for combatting microbial infections.

Identifiants

DOI: 10.1016/j.bmcl.2023.129176 PMID: 36764469
pubmed: 36764469
pii: S0960-894X(23)00054-9
doi: 10.1016/j.bmcl.2023.129176
pii:
doi:

Substances chimiques

Antimicrobial Cationic Peptides 0
Antimicrobial Peptides 0
Anti-Infective Agents 0
Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

129176

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Yiming Wang (Y)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Guilan Zhu (G)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Wei Wang (W)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Yan Zhang (Y)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Yong Zhu (Y)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Jingjing Wang (J)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Ming Geng (M)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Hongxia Lu (H)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Yajun Chen (Y)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Minghui Zhou (M)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Jing Chen (J)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Fangyan Zhang (F)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Junjie Yang (J)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

Xiaozhong Cheng (X)

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China. Electronic address: chengxiaozhong@hfnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Rational design of HJH antimicrobial peptides...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides antimicrobiens › Rational design of HJH antimicrobial peptides...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Rational design of HJH antimicrobial peptides...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Rational design of HJH antimicrobial peptides...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Rational design of HJH antimicrobial peptides...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Rational design of HJH antimicrobial peptides...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Rational design of HJH antimicrobial peptides...